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Mycophenolate Mofetil Improves Exercise Tolerance in Systemic Sclerosis Patients with Interstitial Lung Disease: A Pilot Study
- Source :
- Rheumatology and Therapy, Rheumatology and Therapy, Vol 7, Iss 4, Pp 1037-1044 (2020)
- Publication Year :
- 2020
-
Abstract
- Introduction Systemic sclerosis (SSc) is an autoimmune disease characterized by the overproduction of collagen leading to fibrosis of the skin and internal organs. Interstitial lung disease (ILD) is one of the major causes of death in patients with SSc. Exercise tolerance can be investigated by cardio-pulmonary exercise testing (CPET). First-line therapies in patients with SSc associated with ILD (SSc-ILD) include cyclophosphamide and mycophenolate mofetil (MMF). The aim of this study was to evaluate the response of patients with SSc-ILD to MMF by means of CPET. Methods Ten consecutive SSc patients were enrolled in this study. All SSc patients underwent clinical evaluation, echocardiography, pulmonary function tests, high-resolution computed tomography (HRCT) and CPET at baseline and after 2 years of therapy with MMF. Results After 24 months of treatment with MMF (target dose 1500 mg twice daily), forced vitality capacity, diffusing capacity of the lungs for carbon monoxide and systolic pulmonary arterial pressure had not improved significantly and there were no significant differences in HRCT findigns. In addition, peak oxygen uptake (V′O2 peak) and ventilatory equivalents for carbon dioxide production (V′E/V′CO2 slope) had not improved significantly. In contrast, there was a significant improvement from baseline to 24 months of treatment in the respiratory exchange ratio [median (interquartile range): 1.07 (0.92–1.22) vs. 1.26 (1.22–1.28), respectively; p
- Subjects :
- medicine.medical_specialty
Cardio-pulmonary exercise testing
Interstitial lung disease
Mycophenolate mofetil
Systemic sclerosis
Cyclophosphamide
Diseases of the musculoskeletal system
Pulmonary function testing
Rheumatology
Interquartile range
Diffusing capacity
Internal medicine
medicine
Immunology and Allergy
Respiratory exchange ratio
business.industry
Brief Report
VO2 max
medicine.disease
RC925-935
Cardiology
business
medicine.drug
Subjects
Details
- ISSN :
- 21986576
- Volume :
- 7
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Rheumatology and therapy
- Accession number :
- edsair.doi.dedup.....6d3e764b722251a237b386569c229eb5