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The Role of Epstein-Barr Virus in Adults With Bronchiectasis: A Prospective Cohort Study
- Source :
- Open Forum Infectious Diseases, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, instname, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
- Publication Year :
- 2020
- Publisher :
- OXFORD UNIV PRESS INC, 2020.
-
Abstract
- Background Epstein-Barr virus (EBV) is implicated in the progression of chronic obstructive pulmonary disease. We aimed to determine whether EBV correlates with bronchiectasis severity, exacerbations, and progression. Methods We collected induced sputum in healthy controls and spontaneous sputum at 3–6-month intervals and onset of exacerbations in bronchiectasis patients between March 2017 and October 2018. EBV DNA was detected with quantitative polymerase chain reaction. Results We collected 442 sputum samples from 108 bronchiectasis patients and 50 induced sputum samples from 50 healthy controls. When stable, bronchiectasis patients yielded higher detection rates of EBV DNA (48.1% vs 20.0%; P = .001), but not viral loads (mean log10 load, 4.45 vs 4.76; P = .266), compared with controls; 64.9% of patients yielded consistent detection status between 2 consecutive stable visits. Neither detection rate (40.8% vs 48.1%; P = .393) nor load (mean log10 load, 4.34 vs 4.45; P = .580) differed between the onset of exacerbations and stable visits, nor between exacerbations and convalescence. Neither detection status nor viral loads correlated with bronchiectasis severity. EBV loads correlated negatively with sputum interleukin-1β (P = .002), CXC motif chemokine-8 (P = .008), and tumor necrosis factor–α levels (P = .005). Patients initially detected with, or repeatedly detected with, EBV DNA had significantly faster lung function decline and shorter time to next exacerbations (both P < .05) than those without. Detection of EBV DNA was unrelated to influenza virus and opportunistic bacteria (all P > .05). The EBV strains detected in bronchiectasis patients were phylogenetically homologous. Conclusions Patients with detection of EBV DNA have a shorter time to bronchiectasis exacerbations. EBV may contribute to bronchiectasis progression.<br />The role of chronic viral infections in bronchiectasis is unclear. In this prospective study, we summarize the association between viral loads or detection rate and the clinical status as well as inflammatory response of bronchiectasis.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Exacerbation
media_common.quotation_subject
airway inflammation
Gastroenterology
human herpes virus–4
Pulmonary function testing
03 medical and health sciences
0302 clinical medicine
exacerbation
Internal medicine
medicine
Major Article
Prospective cohort study
media_common
Bronchiectasis
human herpes virus-4
business.industry
Convalescence
lung function
medicine.disease
Editor's Choice
030104 developmental biology
Infectious Diseases
Real-time polymerase chain reaction
AcademicSubjects/MED00290
030228 respiratory system
Oncology
chronic airway disease
Sputum
medicine.symptom
business
Viral load
chronic viral infection
Subjects
Details
- ISSN :
- 23288957
- Database :
- OpenAIRE
- Journal :
- Open Forum Infectious Diseases, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, instname, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
- Accession number :
- edsair.doi.dedup.....6d3a9f06bb6551f730f825313b7e905d