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Impact of TSPO Receptor Polymorphism on [18F]GE-180 Binding in Healthy Brain and Pseudo-Reference Regions of Neurooncological and Neurodegenerative Disorders
- Source :
- Life; Volume 11; Issue 6; Pages: 484, Life 11(6), 484-(2021). doi:10.3390/life11060484, Life, Vol 11, Iss 484, p 484 (2021), Life
- Publication Year :
- 2021
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2021.
-
Abstract
- TSPO-PET tracers are sensitive to a single-nucleotide polymorphism (rs6971-SNP), resulting in low-, medium- and high-affinity binders (LABs, MABs and HABS), but the clinical relevance of [18F]GE-180 is still unclear. We evaluated the impact of rs6971-SNP on in vivo [18F]GE-180 binding in a healthy brain and in pseudo-reference tissue in neuro-oncological and neurodegenerative diseases. Standardized uptake values (SUVs) of [18F]GE-180-PET were assessed using a manually drawn region of interest in the frontoparietal and cerebellar hemispheres. The SUVs were compared between the LABs, MABs and HABs in control, glioma, four-repeat tauopathy (4RT) and Alzheimer’s disease (AD) subjects. Second, the SUVs were compared between the patients and controls within their rs6971-subgroups. After excluding patients with prior therapy, 24 LABs (7 control, 5 glioma, 6 4RT and 6 AD) were analyzed. Age- and sex-matched MABs (n = 38) and HABs (n = 50) were selected. The LABs had lower frontoparietal and cerebellar SUVs when compared with the MABs and HABs, but no significant difference was observed between the MABs and HABs. Within each rs6971 group, no SUV difference between the patients and controls was detected in the pseudo-reference tissues. The rs6971-SNP affects [18F]GE-180 quantification, revealing lower binding in the LABs when compared to the MABs and HABs. The frontoparietal and cerebellar ROIs were successfully validated as pseudo-reference regions.
- Subjects :
- Pathology
medicine.medical_specialty
Science
4R-tauopathy
microglia
Article
General Biochemistry, Genetics and Molecular Biology
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
TSPO-PET
In vivo
Polymorphism (computer science)
Glioma
ddc:570
neurodegeneration
Alzheimer’s disease
neuro-oncology
medicine
Clinical significance
Receptor
Ecology, Evolution, Behavior and Systematics
Microglia
business.industry
allergology
Neurodegeneration
Neurooncology
Paleontology
medicine.disease
medicine.anatomical_structure
Space and Planetary Science
Tauopathy
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 20751729
- Database :
- OpenAIRE
- Journal :
- Life; Volume 11; Issue 6; Pages: 484
- Accession number :
- edsair.doi.dedup.....6d3a266985f6a79d537efb0665e81f27
- Full Text :
- https://doi.org/10.3390/life11060484