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Triterpene saponins from Antonia ovata leaves
- Publication Year :
- 2012
-
Abstract
- Six pentacyclic triterpenoid saponins, named antoniosides E-J along with two known alkaloids, were isolated from the leaves of Antonia ovata. Their structures were determined by the extensive use of 1D and 2D-NMR experiments along with HRESIMS analysis and acid hydrolysis. All isolated saponins contained the same pentasaccharide chain: 3-O-[beta-D-glucopyranosyl-(1 -> 2)]-[beta-D-glucopyranosyl-(1 -> 4)]-[beta-D-glucopyranosyl-(1 -> 3)-alpha-L-arabinopyranosyl(1 -> 6)]-beta-D-glucopyranoside, linked at C-3 of esterified derivatives of polyhydroxyoleanene triterpenoids (theasapogenol A and 15 alpha-hydroxy-theasapogenol A). Isolated compounds were evaluated for their cytotoxic activity against KB cell line by a WST-1 assay, and the IC50 values ranged from 3.3 to 5.3 mu M.
- Subjects :
- Antonia ovata
Stereochemistry
Plant Science
Horticulture
Biochemistry
KB Cells
Triterpenoid saponins
Triterpenoid
Triterpene
Humans
Nuclear Magnetic Resonance, Biomolecular
Molecular Biology
chemistry.chemical_classification
Theasapogenol A
biology
Cytotoxic activity
General Medicine
Loganiaceae
15 alpha-Hydroxy-theasapogenol A
Saponins
biology.organism_classification
Antineoplastic Agents, Phytogenic
Triterpenes
Plant Leaves
carbohydrates (lipids)
Pentacyclic triterpenoid
chemistry
Acid hydrolysis
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....6d3551a66452a24c794bc087b0675111