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Muscle MRI of classic infantile pompe patients: Fatty substitution and edema‐like changes
- Source :
- Muscle & Nerve. 55:841-848
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Introduction: The aim of this study was to evaluate the muscle MRI pattern of 9 patients (median age: 6.5±2.74 years) affected by classic infantile-onset Pompe disease (IOPD) who were treated with enzyme replacement therapy (ERT). Methods: We performed and qualitatively scored T1-weighted (T1-w) sequences of the facial, shoulder girdle, paravertebral, and lower limb muscles and short-tau inversion recovery (STIR) sequences of the lower limbs using the Mercuri and Morrow scales, respectively. Results: On T1-w images, mild (grade 1) or moderate (grade 2) involvement was found in the tongue in 6 of 6 patients and in the adductor magnus muscle in 6 of 9. STIR hyperintensity was detected in all areas examined, categorized as limited to mild in 5 of 8 patients. Discussion: On T1-w sequences, mild/moderate adipose substitution in the adductor magnus and tongue muscles was documented. STIR edema-like alterations of thigh and calf muscles are novel findings. Correlations with biopsy findings and clinical parameters are needed to fully understand these findings. This article is protected by copyright. All rights reserved.
- Subjects :
- Male
Adductor magnus muscle
Physiology
Thigh
030218 nuclear medicine & medical imaging
03 medical and health sciences
Cellular and Molecular Neuroscience
Gastrocnemius muscle
0302 clinical medicine
Semimembranosus muscle
Tongue
Physiology (medical)
Image Processing, Computer-Assisted
medicine
Edema
Humans
Child
Muscle, Skeletal
Pelvic girdle
Glycogen Storage Disease Type II
business.industry
Anatomy
Magnetic Resonance Imaging
Hyperintensity
medicine.anatomical_structure
Adipose Tissue
Child, Preschool
Shoulder girdle
Female
Neurology (clinical)
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 10974598 and 0148639X
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Muscle & Nerve
- Accession number :
- edsair.doi.dedup.....6d34e7bbe81611cfb14c4aa0274e6a8e