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Clinicopathological Analysis of Hepatocellular Adenoma According to New Bordeaux Classification: Report of Eight Korean Cases
- Source :
- Korean Journal of Pathology
- Publication Year :
- 2013
- Publisher :
- The Korean Society of Pathologists and The Korean Society for Cytopathology, 2013.
-
Abstract
- Background Hepatocellular adenoma (HCA) is a rare benign tumor of the liver. A subtype classification of HCA (hepatocyte nuclear factor 1α [HNF1α]-mutated, β-catenin-mutated HCA, inflammatory HCA, and unclassified HCA) has recently been established based on a single institutional review of a HCA series by the Bordeaux group. Methods We used histologic and immunohistochemical parameters to classify and evaluate eight cases from our institution. We evaluated the new classification method and analyzed correlations between our results and those of other reports. Results Seven of our eight cases showed histologic and immunohistochemical results consistent with previous reports. However, one case showed overlapping histologic features, as previously described by the Bordeaux group. Four cases showed glutamine synthetase immunohistochemical staining inconsistent with their classification, indicating that glutamine synthetase staining may not be diagnostic for β-catenin-mutated HCA. HNF1α-mutated HCA may be indicated by the absence of liver fatty acid binding protein expression. Detection of amyloid A may indicate inflammatory HCA. HCA with no mutation in the HNF1α or β-catenin genes and no inflammatory protein expression is categorized as unclassified HCA. Conclusions Although the new classification is now generally accepted, validation through follow-up studies is necessary.
- Subjects :
- Pathology
medicine.medical_specialty
Adenoma
business.industry
Liver cell
Subtype
Beta catenin
Hepatocyte nuclear factor 1-alpha
Hepatocellular adenoma
medicine.disease
Pathology and Forensic Medicine
Benign tumor
Adenoma, liver cell
medicine
Original Article
Serum amyloid A protein
Subtype classification
business
Subjects
Details
- ISSN :
- 20928920 and 17381843
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Korean Journal of Pathology
- Accession number :
- edsair.doi.dedup.....6d3474d1cb6efcb12fa9fa74135b1dc0