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Location-Specific Thickness Patterns in Intermediate Age-Related Macular Degeneration Reveals Anatomical Differences in Multiple Retinal Layers
- Source :
- Investigative Ophthalmology & Visual Science
- Publication Year :
- 2021
- Publisher :
- Association for Research in Vision and Ophthalmology (ARVO), 2021.
-
Abstract
- Purpose To examine individual retinal layers’ location-specific patterns of thicknesses in intermediate age-related macular degeneration (iAMD) using optical coherence tomography (OCT). Methods OCT macular cube scans were retrospectively acquired from 84 iAMD eyes of 84 participants and 84 normal eyes of 84 participants propensity-score matched on age, sex, and spherical equivalent refraction. Thicknesses of the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer + Henle's fiber layer (ONL+HFL), inner- and outer-segment layers (IS/OS), and retinal pigment epithelium to Bruch's membrane (RPE-BM) were calculated across an 8 × 8 grid (total 24° × 24° area). Location-specific analysis was performed using cluster(normal) and grid(iAMD)-to-cluster(normal) comparisons. Results In iAMD versus normal eyes, the central RPE-BM was thickened (mean difference ± SEM up to 27.45% ± 7.48%, P < 0.001; up to 7.6 SD-from-normal), whereas there was thinned outer (OPL, ONL+HFL, and non-central RPE-BM, up to −6.76% ± 2.47%, P < 0.001; up to −1.6 SD-from-normal) and inner retina (GCL and IPL, up to −4.83% ± 1.56%, P < 0.01; up to −1.7 SD-from-normal) with eccentricity-based effects. Interlayer correlations were greater against the ONL+HFL (mean |r| ± SEM 0.19 ± 0.03, P = 0.14 to < 0.0001) than the RPE-BM (0.09 ± 0, P = 0.72 to < 0.0001). Conclusions Location-specific analysis suggests altered retinal anatomy between iAMD and normal eyes. These data could direct clinical diagnosis and monitoring of AMD toward targeted locations.
- Subjects :
- Male
Retinal Ganglion Cells
medicine.medical_specialty
anatomy
genetic structures
Visual Acuity
Nerve fiber layer
Outer plexiform layer
Retinal Pigment Epithelium
Retina
Macular Degeneration
chemistry.chemical_compound
topography
Ophthalmology
medicine
Humans
Propensity Score
Outer nuclear layer
age-related macular degeneration
Ganglion cell layer
Aged
Retrospective Studies
Retinal pigment epithelium
Chemistry
Retinal
Middle Aged
Inner plexiform layer
thickness
eye diseases
medicine.anatomical_structure
OCT
Female
Bruch Membrane
sense organs
Tomography, Optical Coherence
clustering
Follow-Up Studies
Subjects
Details
- ISSN :
- 15525783
- Volume :
- 62
- Database :
- OpenAIRE
- Journal :
- Investigative Opthalmology & Visual Science
- Accession number :
- edsair.doi.dedup.....6d2f3415efc4ef93673fcfcf268ab1d9