Back to Search
Start Over
CX3CL1 and CX3CR1 Expression in Human Brain Tissue: Noninflammatory Control versus Multiple Sclerosis
- Source :
- Journal of Neuropathology & Experimental Neurology. 62:899-907
- Publication Year :
- 2003
- Publisher :
- Oxford University Press (OUP), 2003.
-
Abstract
- An important role for CX3CL1 in neuroinflammation and neurodegeneration has been suggested in recent publications. In this study, we compared the expression of CX3CL1 and its receptor CX3CR1 in human brain tissue derived from control patients without neurological complications and in multiple sclerosis (MS) patients. Results from this study demonstrate that CX3CL1 is constitutively expressed in human central nervous system (CNS) astrocytes in vivo and under basal conditions in human adult astrocyte cultures. CX3CR1 is expressed on astrocytes and microglial cells both in vivo and in vitro. Chemotaxis assay shows a functional response upon CX3CR1 signaling in microglial cells. Although CX3CL1 expression is upregulated in cultured astrocytes in response to proinflammatory cytokines, no evidence for expression differences of CX3CL1 between control patients and MS patients was found. Our data suggest that CX3CL1 has more general physiological functions, which occur also in the absence of proinflammatory conditions.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Multiple Sclerosis
Central nervous system
CX3C Chemokine Receptor 1
Biology
Pathology and Forensic Medicine
Proinflammatory cytokine
Cellular and Molecular Neuroscience
CX3CR1
medicine
Humans
Cells, Cultured
Neuroinflammation
Aged
Aged, 80 and over
Microglia
Chemokine CX3CL1
Multiple sclerosis
Brain
Membrane Proteins
General Medicine
Human brain
Middle Aged
medicine.disease
Chemokines, CX3C
medicine.anatomical_structure
Gene Expression Regulation
Neurology
Astrocytes
Encephalitis
Female
Receptors, Chemokine
Neurology (clinical)
Astrocyte
Subjects
Details
- ISSN :
- 15546578 and 00223069
- Volume :
- 62
- Database :
- OpenAIRE
- Journal :
- Journal of Neuropathology & Experimental Neurology
- Accession number :
- edsair.doi.dedup.....6d28f564ca8b5b819fd7ebd93f896709