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Effects of hypolipidemic agent nordihydroguaiaretic acid on lipid droplets and hepatitis C virus
- Source :
- Hepatology (Baltimore, Md.). 54(6)
- Publication Year :
- 2011
-
Abstract
- Hepatitis C virus (HCV) relies on host lipid metabolic pathways for its replication, assembly, secretion, and entry. HCV induces de novo lipogenesis, inhibits β-oxidation, and lipoprotein export resulting in a lipid-enriched cellular environment critical for its proliferation. We investigated the effects of a hypolipidemic agent, nordihydroguaiaretic acid (NDGA), on host lipid/fatty acid synthesis and HCV life cycle. NDGA negated the HCV-induced alteration of host lipid homeostasis. NDGA decreased sterol regulatory element binding protein (SREBP) activation and enhanced expression of genes involved in β-oxidation. NDGA inhibited very low-density lipoprotein (VLDL) secretion by affecting mediators of VLDL biosynthesis. Lipid droplets (LDs), the neutral lipid storage organelles, play a key role in HCV morphogenesis. HCV induces accumulation and perinuclear distribution of LDs, whereas NDGA most notably reduced the overall number and increased the average size of LDs. The antiviral effects of NDGA resulted in reduced HCV replication and secretion. Conclusion: NDGA-mediated alterations of host lipid metabolism, LD morphology, and VLDL transport appear to negatively influence HCV proliferation. (HEPATOLOGY 2011;)
- Subjects :
- Very low-density lipoprotein
Hepacivirus
Biology
Lipoproteins, VLDL
Virus Replication
Antiviral Agents
Article
chemistry.chemical_compound
Lipid droplet
Cell Line, Tumor
medicine
Humans
Masoprocol
Fatty acid synthesis
Hypolipidemic Agents
Organelles
Hepatology
Lipogenesis
Lipid metabolism
respiratory system
Lipid Metabolism
Cell biology
Sterol regulatory element-binding protein
Nordihydroguaiaretic acid
chemistry
Biochemistry
lipids (amino acids, peptides, and proteins)
medicine.drug
Subjects
Details
- ISSN :
- 15273350
- Volume :
- 54
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Hepatology (Baltimore, Md.)
- Accession number :
- edsair.doi.dedup.....6d1a8f8a790e09a3fee48353cc4d05e8