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Two cases in whom pyrazinamide does not inhibit the uricosuric action of benzbromarone
- Source :
- Nephron. 61(4)
- Publication Year :
- 1992
-
Abstract
- The 2 subjects were a diabetic male with renal hypouricemia and a healthy male with normouricemia. In these subjects, 200 mg of benzbromarone increased fractional uric acid clearance (FUa) and 3.0 g of pyrazinamide decreased FUa. However, pyrazinamide did not inhibit the uricosuric action of benzbromarone at all on the administration of 3.0 g of pyrazinamide together with 200 mg of benzbromarone. These results indicated that in these cases, the relative role of each component could not be determined on the basis of the hypothetical four-component model.
- Subjects :
- Adult
Male
medicine.medical_specialty
Uricosuric
Kidney
Benzbromarone
chemistry.chemical_compound
Internal medicine
Diabetes mellitus
medicine
Humans
Drug Interactions
Hypouricemia
business.industry
Pyrazinamide
Drug interaction
medicine.disease
Uric Acid
Endocrinology
chemistry
Mechanism of action
Diabetes Mellitus, Type 2
Uric acid
Female
Kidney Diseases
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 16608151
- Volume :
- 61
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Nephron
- Accession number :
- edsair.doi.dedup.....6d154ef8074d2e7d0066841a18bcd852