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Polysaccharide isolated from Phellinus linteus mycelia exerts anti-inflammatory effects via MAPK and PPAR signaling pathways
- Source :
- Carbohydrate Polymers. 200:487-497
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- In the present study, the anti-inflammatory function of Phellinus linteus polysaccharide (PLP) was investigated in animal and cell inflammation models, and the anti-inflammatory mechanism of PLP was also explored. Sixty 8-week ICR mice were randomly divided into 3 groups, and DSS group and DSS + PLP group mice received 2.0% DSS and PLP was orally administered at 500 mg/kg/day. Our data showed that PLP administration obviously improved the health status of mice and inhibited DSS-induced pathological alterations and significantly reduced inflammatory cytokine expressions in the colonic tissues. In lipopolysaccharide-induced inflammation cell model, PLP supplement also significantly reduced inflammatory cytokine expressions and inhibited MAPK pathway as well as the translocations of NF-κB and AP-1. Meanwhile, PLP supplement regulated PPARα and PPARγ phosphorylation and blocked MAPK activation. Taken together, PLP exhibits anti-inflammatory function and its molecular mechanism may be involved in MAPK and PPAR signal pathways, which reduce the expressions of inflammatory cytokines.
- Subjects :
- Male
0301 basic medicine
MAPK/ERK pathway
Polymers and Plastics
medicine.medical_treatment
Peroxisome Proliferator-Activated Receptors
Anti-Inflammatory Agents
Peroxisome proliferator-activated receptor
Pharmacology
Mice
chemistry.chemical_compound
0302 clinical medicine
immune system diseases
Malondialdehyde
Materials Chemistry
Phosphorylation
chemistry.chemical_classification
biology
NF-kappa B
Hep G2 Cells
Cytokine
Phellinus linteus
030220 oncology & carcinogenesis
Cytokines
lipids (amino acids, peptides, and proteins)
medicine.symptom
Colon
MAP Kinase Signaling System
medicine.drug_class
chemical and pharmacologic phenomena
Inflammation
Anti-inflammatory
Proinflammatory cytokine
03 medical and health sciences
medicine
Animals
Humans
Nitrites
Cell Proliferation
Peroxidase
Basidiomycota
Macrophages
Organic Chemistry
Fungal Polysaccharides
NF-κB
biology.organism_classification
nervous system diseases
Transcription Factor AP-1
RAW 264.7 Cells
030104 developmental biology
Gene Expression Regulation
chemistry
Spleen
Subjects
Details
- ISSN :
- 01448617
- Volume :
- 200
- Database :
- OpenAIRE
- Journal :
- Carbohydrate Polymers
- Accession number :
- edsair.doi.dedup.....6d13dc950b2a49b7f5e4442867542722