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Removal of the ovarian surface epithelium from the rabbit ovary—a cause of adhesions following a standard injury
- Source :
- Human Reproduction. 9:497-500
- Publication Year :
- 1994
- Publisher :
- Oxford University Press (OUP), 1994.
-
Abstract
- To assess the effect of the removal of ovarian surface epithelium on repair, a standard injury was induced in the ovaries of 10 rabbits. In one ovary the surface cells were denuded, and in the other they were left intact. The effect on adhesion formation was assessed at 12 days. Adhesions were assessed by visual inspection at laparotomy and histological examination of adhesion formation, including a stereological assessment of scar volume. On visual assessment the overall adhesion scores for the denuded ovaries were greater than for the intact ovaries. Histology showed the adhesions were attached only to the site of injury. The Fallopian tube was adherent to 35 and 4% of the denuded and intact ovarian segments respectively (P = 0.003). The scar volumes for each side were similar. After 12 days there was only partial re-epithelialization on the denuded ovaries. Electron microscopy confirmed the slow healing, with much of the surface still covered by a fibrinous-like exudate. The findings of this small study lend further weight to the importance of the surface epithelium in the control of adhesion formation. Standard surgical procedures may generate adhesions by the inadvertent denuding of surface epithelium from adjacent healthy tissues, possibly by the loss of plasminogen activator activity that is found in the mesothelium of the peritoneum. This study highlights the importance of controlling for inadvertent cell loss whilst investigating methods for adhesion prevention.
- Subjects :
- Pathology
medicine.medical_specialty
Adhesion (medicine)
Tissue Adhesions
Ovary
Biology
Epithelium
Cicatrix
Peritoneum
medicine
Animals
Ovarian Diseases
Wound Healing
Rehabilitation
Obstetrics and Gynecology
Histology
medicine.disease
Mesothelium
Microscopy, Electron
medicine.anatomical_structure
Reproductive Medicine
Microscopy, Electron, Scanning
Female
Rabbits
Wound healing
Fallopian tube
Subjects
Details
- ISSN :
- 14602350 and 02681161
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Human Reproduction
- Accession number :
- edsair.doi.dedup.....6d10adec9689b1bc12cd6325ecb01736