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Effects and Mechanisms of Probiotics, Prebiotics, Synbiotics, and Postbiotics on Metabolic Diseases Targeting Gut Microbiota: A Narrative Review
- Source :
- Nutrients, Nutrients, Vol 13, Iss 3211, p 3211 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- Metabolic diseases are serious threats to public health and related to gut microbiota. Probiotics, prebiotics, synbiotics, and postbiotics (PPSP) are powerful regulators of gut microbiota, thus possessing prospects for preventing metabolic diseases. Therefore, the effects and mechanisms of PPSP on metabolic diseases targeting gut microbiota are worth discussing and clarifying. Generally, PPSP benefit metabolic diseases management, especially obesity and type 2 diabetes mellitus. The underlying gut microbial-related mechanisms are mainly the modulation of gut microbiota composition, regulation of gut microbial metabolites, and improvement of intestinal barrier function. Moreover, clinical trials showed the benefits of PPSP on patients with metabolic diseases, while the clinical strategies for gestational diabetes mellitus, optimal formula of synbiotics and health benefits of postbiotics need further study. This review fully summarizes the relationship between probiotics, prebiotics, synbiotics, postbiotics, and metabolic diseases, presents promising results and the one in dispute, and especially attention is paid to illustrates potential mechanisms and clinical effects, which could contribute to the next research and development of PPSP.
- Subjects :
- obesity
Synbiotics
type 2 diabetes mellitus
Review
Gut flora
Health benefits
Bioinformatics
digestive system
metabolic diseases
Medicine
Humans
TX341-641
postbiotics
Nutrition and Dietetics
biology
gut microbiota
Bacteria
Nutrition. Foods and food supply
business.industry
Probiotics
Type 2 Diabetes Mellitus
biology.organism_classification
medicine.disease
Obesity
gestational diabetes mellitus
Gastrointestinal Microbiome
Prebiotics
Narrative review
business
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 20726643
- Volume :
- 13
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....6d0720ecf020d788c445fd9ac0eb6672