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Chromosomal stability in buccal cells was linked to age but not affected by exercise and nutrients - Vienna Active Ageing Study (VAAS), a randomized controlled trial
- Source :
- Redox Biology, Vol 28, Iss, Pp-(2020), Redox Biology
- Publication Year :
- 2020
- Publisher :
- Elsevier, 2020.
-
Abstract
- The purpose of this study was to investigate the effect of six months strength training with or without supplementing protein and vitamins, on chromosomal integrity of buccal cells in institutionalized elderly. One hundred seventeen women and men (65–98 years) performed either resistance training (RT), RT combined with a nutritional supplement (RTS) or cognitive training (CT) twice per week for six months. Participants’ fitness was measured using the 6 min walking, the chair rise, and the handgrip strength test. Genotoxicity and cytotoxicity parameters were investigated with the Buccal Micronucleus Cytome (BMcyt) assay. Six minutes walking and chair rise performance improved significantly, however, no changes of the parameters of the BMcyt were detected. Age and micronuclei (MN) frequency correlated significantly, for both women (r = 0.597, p = 0.000) and men (r = 0.508, p = 0.000). Squared regressions revealed a significant increase in the MN frequency of buccal cells with age (R2 = 0.466, p = 0.000). Interestingly and contrary to what was shown in blood lymphocytes, chromosomal damage in buccal cells increases until very old age, which might qualify them as a valid biomarker for aging. Unexpectedly, in this group of institutionalized elderly, resistance training using elastic bands had no effect on chromosomal damage in buccal cells.<br />Graphical abstract Image 1<br />Highlights • Mutation in buccal cells increased until very old age – a new aging biomarker? • Chromosomal damage in buccal cells was age-dependent and equal for women and men. • Strength training improved fitness but not mutagenicity in buccal cells of elderly.
- Subjects :
- Aging biomarker
Male
0301 basic medicine
Aging
Strength training
Clinical Biochemistry
Buccal swab
Physiology
Walk Test
Micronuclei
medicine.disease_cause
Biochemistry
law.invention
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
Life-expectancy
law
Genome stability
Chromosomal Instability
medicine
Humans
10. No inequality
lcsh:QH301-705.5
Aged
Aged, 80 and over
Mouth
lcsh:R5-920
Hand Strength
business.industry
Organic Chemistry
Resistance training
Resistance Training
Buccal administration
3. Good health
030104 developmental biology
lcsh:Biology (General)
Austria
Dietary Supplements
Micronucleus test
DNA damage
Female
Micronucleus
business
lcsh:Medicine (General)
030217 neurology & neurosurgery
Genotoxicity
Research Paper
Subjects
Details
- Language :
- English
- ISSN :
- 22132317
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Redox Biology
- Accession number :
- edsair.doi.dedup.....6d03e8b22ce395453c20a96ab0d68ae8