Back to Search
Start Over
Full-length TrkB variant in NSCLC is associated with brain metastasis
- Source :
- BioMed Research International, BioMed Research International, Vol 2020 (2020)
- Publication Year :
- 2020
- Publisher :
- Hindawi Limited, 2020.
-
Abstract
- Despite remarkable therapeutic advances have been made in the last few decades, non-small cell lung cancer (NSCLC) is still one of the leading causes of death worldwide. Brain metastases are a common complication of a wide range of human malignancies and in particular NSCLC. Brain-derived neurotrophic factor (BDNF), binding its high-affinity tyrosine kinase B receptor, has been shown to promote cancer progression and metastasis. We hereby investigated the expression of the BDNF and its TrkB receptor in its full-length and truncated isoform T1, in samples from primary adenocarcinomas (ADKs) of the lung and in their metastasis to evaluate if their expression was related to preferential tumor entry into the central nervous system (CNS). By immunohistochemistry, 80% of the ADKs that metastasize to central nervous system expressed TrkB receptor compared to 33% expressing of ADKs without CNS metastasis. Moreover, ADKs with CNS metastasis showed an elevated expression of the full-length TrkB receptor. The TrkB receptor FL/T1 ratio was statistically higher in primary ADKs with brain metastasis compared to ADKs without brain metastasis. Our data indicate that TrkB full-length isoform expression in primary ADK cells may be associated with higher risk to develop brain metastasis. Therefore, TrkB receptor may possess prognostic and therapeutic implications in lung ADK.
- Subjects :
- Male
Cellular pathology
Lung Neoplasms
Article Subject
TrkB receptor
Tropomyosin receptor kinase B
General Biochemistry, Genetics and Molecular Biology
Metastasis
tropomyosins
ADK
Neurotrophic factors
Carcinoma, Non-Small-Cell Lung
Cell Line, Tumor
Spheroids, Cellular
Cell Adhesion
Medicine
Humans
Receptor, trkB
Aged
General Immunology and Microbiology
business.industry
Brain Neoplasms
Brain-Derived Neurotrophic Factor
Cancer
General Medicine
Middle Aged
medicine.disease
Gene Expression Regulation, Neoplastic
nervous system
Mutation
Cancer research
Immunohistochemistry
Female
business
Tyrosine kinase
Brain metastasis
Research Article
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- BioMed Research International, BioMed Research International, Vol 2020 (2020)
- Accession number :
- edsair.doi.dedup.....6cfd933f0e5a91978fc2df9483260453