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Genetic Polymorphism of HLA-G 14-bp Insertion/Deletion in Pancreas Transplant Recipients and Its Association With Type 1 Diabetes Mellitus
- Source :
- Experimental and Clinical Transplantation. 19:154-159
- Publication Year :
- 2021
- Publisher :
- Baskent University, 2021.
-
Abstract
- OBJECTIVES Human leukocyte antigen-G is an immuno-modulatory factor that affects acute allograft rejection and autoimmune diseases such as type 1 diabetes mellitus. In this study, possible associations between human leukocyte antigen-G 14-bp insertion/deletion polymorphism and acute pancreas rejection were investigated. MATERIALS AND METHODS Human leukocyte antigen-G genotyping was assessed in 102 Iranian pancreas transplant recipients (including 41 with acute rejection and 61 with nonacute rejection). Results were compared with 100 individuals in a normal control group. RESULTS No significant differences in genotype frequencies of human leukocyte antigen-G 14-bp insertion / deletion were observed in recipients who had acute rejection episodes. On the other hand, the insertion / insertion genotype was a risk factor for susceptibility to type 1 diabetes mellitus (odds ratio = 3.82, 95% confidence interval, 1.37- 11.22; P = .005). CONCLUSIONS Our results provided evidence revealing that the human leukocyte antigen-G insertion / insertion genotype might be involved in the pathogenesis of type 1 diabetes mellitus.
- Subjects :
- Graft Rejection
Genotype
Human leukocyte antigen
Iran
030230 surgery
Pathogenesis
03 medical and health sciences
0302 clinical medicine
INDEL Mutation
HLA-G
Humans
Medicine
Pancreas
Genotyping
HLA-G Antigens
Transplantation
Type 1 diabetes
Polymorphism, Genetic
business.industry
Odds ratio
medicine.disease
Transplant Recipients
Genotype frequency
Diabetes Mellitus, Type 1
Immunology
030211 gastroenterology & hepatology
Pancreas Transplantation
business
Subjects
Details
- ISSN :
- 21468427 and 13040855
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Experimental and Clinical Transplantation
- Accession number :
- edsair.doi.dedup.....6cef852cce865b30f34901b1f7c42139