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Granuloma formation by muramyl dipeptide associated with branched fatty acids, a structure probably essential for tubercle formation by Mycobacterium tuberculosis
Granuloma formation by muramyl dipeptide associated with branched fatty acids, a structure probably essential for tubercle formation by Mycobacterium tuberculosis
- Source :
- Infection and immunity. 49(1)
- Publication Year :
- 1985
-
Abstract
- Muramyl dipeptide, which does not induce epithelioid granuloma when injected alone dissolved in phosphate-buffered saline, could induce extensive granulomas in guinea pigs when chemically conjugated with branched, but not linear, fatty acids. Peptidoglycan fragments of Staphylococcus epidermidis could evoke epithelioid granulomas when incorporated in a water-in-oil emulsion. These findings suggest the importance of a lipid bound to muramyl dipeptide for granuloma formation. In view of the fact that mycobacteria uniquely contain large amounts of branched fatty acids, it was proposed that the complex of muramyl dipeptide and branched fatty acids, mostly mycolic acids, is a structure in tubercle bacilli responsible for tubercle formation.
- Subjects :
- Tubercle
Immunology
Guinea Pigs
Biology
Microbiology
Guinea pig
Mycobacterium tuberculosis
chemistry.chemical_compound
Structure-Activity Relationship
Staphylococcus epidermidis
hemic and lymphatic diseases
medicine
Animals
Granuloma
Acetylmuramyl-Alanyl-Isoglutamine
Fatty Acids
biology.organism_classification
medicine.disease
bacterial infections and mycoses
Infectious Diseases
chemistry
Biochemistry
Parasitology
Female
Peptidoglycan
Muramyl dipeptide
Research Article
Subjects
Details
- ISSN :
- 00199567
- Volume :
- 49
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Infection and immunity
- Accession number :
- edsair.doi.dedup.....6ce558a5508d6b07f28c71485d01b407