Back to Search
Start Over
Effect of d-cycloserine on fear extinction training in adults with social anxiety disorder
- Source :
- PLoS ONE, PLoS ONE, Vol 14, Iss 10, p e0223729 (2019)
- Publication Year :
- 2019
- Publisher :
- Public Library of Science, 2019.
-
Abstract
- Preclinical and clinical data have shown that D-cycloserine (DCS), a partial agonist at the N-methyl-d-aspartate receptor complex, augments the retention of fear extinction in animals and the therapeutic learning from exposure therapy in humans. However, studies with non-clinical human samples in de novo fear conditioning paradigms have demonstrated minimal to no benefit of DCS. The aim of this study was to evaluate the effects of DCS on the retention of extinction learning following de novo fear conditioning in a clinical sample. Eighty-one patients with social anxiety disorder were recruited and underwent a previously validated de novo fear conditioning and extinction paradigm over the course of three days. Of those, only 43 (53%) provided analyzable data. During conditioning on Day 1, participants viewed images of differently colored lamps, two of which were followed by with electric shock (CS+) and a third which was not (CS-). On Day 2, participants were randomly assigned to receive either 50 mg DCS or placebo, administered in a double-blind manner 1 hour prior to extinction training with a single CS+ in a distinct context. Day 3 consisted of tests of extinction recall and renewal. The primary outcome was skin conductance response to conditioned stimuli, and shock expectancy ratings were examined as a secondary outcome. Results showed greater skin conductance and expectancy ratings in response to the CS+ compared to CS- at the end of conditioning. As expected, this difference was no longer present at the end of extinction training, but returned at early recall and renewal phases on Day 3, showing evidence of return of fear. In contrast to hypotheses, DCS had no moderating influence on skin conductance response or expectancy of shock during recall or renewal phases. We did not find evidence of an effect of DCS on the retention of extinction learning in humans in this fear conditioning and extinction paradigm.
- Subjects :
- Male
Receptor complex
Light
Antimetabolites
medicine.medical_treatment
Exposure therapy
Social Sciences
Audiology
Extinction, Psychological
0302 clinical medicine
Cognition
Learning and Memory
Behavioral Conditioning
Medicine and Health Sciences
Medicine
Psychology
Fear conditioning
Multidisciplinary
Physics
Electromagnetic Radiation
Social anxiety
Galvanic Skin Response
Anxiety Disorders
Artificial Light
Physical Sciences
Memory Recall
Female
Research Article
Social Anxiety Disorder
Adult
medicine.medical_specialty
Science
Context (language use)
Neuropsychiatric Disorders
Neuroses
03 medical and health sciences
Human Learning
Double-Blind Method
Memory
Mental Health and Psychiatry
Learning
Humans
Behavior
Recall
business.industry
Cognitive Psychology
Biology and Life Sciences
Phobia, Social
Extinction (psychology)
Placebo Effect
030227 psychiatry
Cycloserine
Mental Recall
Conditioning
Conditioned Response
Cognitive Science
business
Fear Conditioning
030217 neurology & neurosurgery
Photic Stimulation
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 14
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....6cd6c1d95a4edad944193dc02785194d