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Genetic variation in Glutathione S-Transferase Omega-1, Arsenic Methyltransferase and Methylene-tetrahydrofolate Reductase, arsenic exposure and bladder cancer: a case–control study
- Source :
- Environmental Health, Environmental Health, Vol 11, Iss 1, p 43 (2012)
- Publisher :
- Springer Nature
-
Abstract
- Background Ingestion of groundwater with high concentrations of inorganic arsenic has been linked to adverse health outcomes, including bladder cancer, however studies have not consistently observed any elevation in risk at lower concentrations. Genetic variability in the metabolism and clearance of arsenic is an important consideration in any investigation of its potential health risks. Therefore, we examined the association between genes thought to play a role in the metabolism of arsenic and bladder cancer. Methods Single nucleotide polymorphisms (SNPs) in GSTO-1, As3MT and MTHFR were genotyped using DNA from 219 bladder cancer cases and 273 controls participating in a case–control study in Southeastern Michigan and exposed to low to moderate ( Results While no single SNP in As3MT was significantly associated with bladder cancer overall, several SNPs were associated with bladder cancer among those exposed to higher arsenic levels. Individuals with one or more copies of the C allele in rs11191439 (the Met287Thr polymorphism) had an elevated risk of bladder cancer (OR = 1.17; 95% CI = 1.04-1.32 per 1 μg/L increase in average exposure). However, no association was observed between average arsenic exposure and bladder cancer among TT homozygotes in the same SNP. Bladder cancer cases were also 60% less likely to be homozygotes for the A allele in rs1476413 in MTHFR compared to controls (OR = 0.40; 95% CI = 0.18-0.88). Conclusions Variation in As3MT and MTHFR is associated with bladder cancer among those exposed to relatively low concentrations of inorganic arsenic. Further investigation is warranted to confirm these findings.
- Subjects :
- Male
Michigan
Health, Toxicology and Mutagenesis
Physiology
Pilot Projects
010501 environmental sciences
01 natural sciences
Polymerase Chain Reaction
Toxicology
Polymorphism (computer science)
Genotype
Urothelial cancer
Medicine
Genetic epidemiology
Glutathione Transferase
0303 health sciences
biology
lcsh:Public aspects of medicine
Homozygote
Environmental exposure
Middle Aged
3. Good health
lcsh:Industrial medicine. Industrial hygiene
Female
chemistry.chemical_element
Single-nucleotide polymorphism
Polymorphism, Single Nucleotide
Risk Assessment
Arsenic
03 medical and health sciences
lcsh:RC963-969
Humans
Genetic Predisposition to Disease
Methylenetetrahydrofolate Reductase (NADPH2)
030304 developmental biology
0105 earth and related environmental sciences
Aged
Bladder cancer
business.industry
Drinking Water
Research
Case-control study
Arsenic methylation
Public Health, Environmental and Occupational Health
lcsh:RA1-1270
Environmental Exposure
Methyltransferases
Single nucleotide polymorphisms
medicine.disease
chemistry
Urinary Bladder Neoplasms
Methylenetetrahydrofolate reductase
Case-Control Studies
biology.protein
business
Subjects
Details
- Language :
- English
- ISSN :
- 1476069X
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Environmental Health
- Accession number :
- edsair.doi.dedup.....6ccb26591ea3b1b95c0154c7614aaf8d
- Full Text :
- https://doi.org/10.1186/1476-069x-11-43