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Utility of Transient Elastography for the Screening of Liver Disease in Patients with Alpha1-Antitrypsin Deficiency
- Source :
- E-Prints Complutense. Archivo Institucional de la UCM, instname, Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona, Journal of Clinical Medicine, Vol 10, Iss 1724, p 1724 (2021), Journal of Clinical Medicine, Volume 10, Issue 8, Scientia
- Publication Year :
- 2021
- Publisher :
- MPDI, 2021.
-
Abstract
- Screening of liver disease in alpha-1 antitrypsin deficiency (AATD) is usually carried out with liver enzymes, with low sensitivity. We conducted a multicenter cross-sectional study aiming to describe the utility of transient elastography for the identification of liver disease in patients with AATD. A total of 148 AATD patients were included. Among these, 54.7% were Pi*ZZ and 45.3% were heterozygous for the Z allele. Between 4.9% and 16.5% of patients had abnormal liver enzymes, without differences among genotypes. Liver stiffness measurement (LSM) was significantly higher in Pi*ZZ individuals than in heterozygous Z (5.6 vs. 4.6 kPa<br />p = 0.001). In total, in 8 (5%) individuals LSM was &gt<br />7.5 kPa, considered significant liver fibrosis, and ≥10 kPa in 3 (1.9%) all being Pi*ZZ. Elevated liver enzymes were more frequently observed in patients with LSM &gt<br />7.5 kPa, but in 5 out of 8 of these patients all liver enzymes were within normal range. In patients with AATD, the presence of abnormal liver enzymes is frequent<br />however, most of these patients do not present significant liver fibrosis. Transient elastography can help to identify patients with liver fibrosis even with normal liver enzymes and should be performed in all Z-allele carriers to screen for liver disease.
- Subjects :
- Gastroenterología y hepatología
Abnormal liver enzymes
medicine.medical_specialty
Transient elastography
Normal liver enzymes
Gastroenterology
Article
Alfa 1-antitripsina
Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Ultrasonography::Elasticity Imaging Techniques [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT]
03 medical and health sciences
Liver disease
0302 clinical medicine
Digestive System Diseases::Liver Diseases::alpha 1-Antitrypsin Deficiency [DISEASES]
Liver stiffness
Internal medicine
Genotype
medicine
In patient
Allele
Other subheadings::Other subheadings::/diagnostic imaging [Other subheadings]
enfermedades del sistema digestivo::enfermedades hepáticas::deficiencia de alfa 1-antitripsina [ENFERMEDADES]
business.industry
alpha1-antitrypsin deficiency
Otros calificadores::Otros calificadores::/diagnóstico por imagen [Otros calificadores]
General Medicine
medicine.disease
transient elastography
enfermedades del sistema digestivo::enfermedades hepáticas [ENFERMEDADES]
Fetge - Malalties - Imatgeria
Digestive System Diseases::Liver Diseases [DISEASES]
030228 respiratory system
Medicine
030211 gastroenterology & hepatology
Alpha1-antitrypsin deficiency
liver disease
business
diagnóstico::técnicas y procedimientos diagnósticos::diagnóstico por imagen::ecografía::elastografía [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS]
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- E-Prints Complutense. Archivo Institucional de la UCM, instname, Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona, Journal of Clinical Medicine, Vol 10, Iss 1724, p 1724 (2021), Journal of Clinical Medicine, Volume 10, Issue 8, Scientia
- Accession number :
- edsair.doi.dedup.....6cbf81d199194d7683f19ba6df9820ca