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Russell body gastritis/duodenitis: A case series and description of immunoglobulin light chain restriction
- Source :
- Clinics and Research in Hepatology and Gastroenterology. 38:e89-e97
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Russell body esophago-gastro-duodenitis is an unusual form of chronic inflammation, with only 22 cases being reported in PubMed. However, the prevalence and clinical significance remain unknown. This report describes the clinico-pathological characteristics of nine cases of Russell body gastritis (RBG) and one case of Russell body duodentitis (RBD), with nonspecific endoscopic appearance. The Mott cells (plasma cells with Russell bodies) showed κ light chain restriction in eight gastritis cases and λ light chain restriction in the duodentitis case, and there were no histological features that suggested lymphoma. Thus, a diagnosis of monoclonal RBG/RBD was made. Helicobacter pylori infection was found in 55.6% of RBG cases and in the RBD case. And, the clinical follow-up evaluations were uneventful. This report is the first study to describe this benign disease entity with monoclonality on a large-scale basis. In addition, the monoclonality of Mott cells cannot be used as evidence of an existing neoplastic lesion, and taken together, these findings may indicate a reactive process.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Helicobacter pylori infection
Plasma Cells
Russell bodies
Immunoglobulin light chain
Young Adult
Duodenitis
Humans
Medicine
Clinical significance
Aged
Hepatology
business.industry
Gastroenterology
Middle Aged
medicine.disease
Lymphoma
Gastritis
Chronic Disease
Monoclonal
Female
Immunoglobulin Light Chains
medicine.symptom
business
Subjects
Details
- ISSN :
- 22107401
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Clinics and Research in Hepatology and Gastroenterology
- Accession number :
- edsair.doi.dedup.....6cbdd514b14401a97a1e02423870e504