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Radiation therapy for nasopharyngeal carcinoma: the predictive value of interim survival assessment
- Source :
- Journal of Radiation Research
- Publication Year :
- 2016
- Publisher :
- Oxford University Press (OUP), 2016.
-
Abstract
- Pretreatment characteristics are suggested as predictive and/or prognostic factors for nasopharyngeal carcinoma (NPC); however, individual tumor radiosensitivities have previously not been considered. As boost planning is recommended for NPC, we performed interim assessments of magnetic resonance (MR) images for boost planning and retrospectively evaluated their predictive value for the survival of NPC patients. Radiation therapy via elective nodal irradiation (median dose: 39.6 Gy) with/without chemotherapy was used to treat 63 NPC patients. Boost irradiation (median total dose: 70 Gy) was performed based on the interim assessment. The largest lymph node (LN) was measured on MR images acquired at the time of interim assessment. The site of first failure was local in 8 (12.7%), regional in 7 (11.1%), and distant in 12 patients (19.0%). All 7 patients with regional failure harbored LNs ≥15 mm at interim assessment. We divided the 63 patients into two groups based on LN size [large (≥15 mm), n = 10 and small (
- Subjects :
- Adult
Male
Adolescent
Health, Toxicology and Mutagenesis
medicine.medical_treatment
Nasopharyngeal neoplasm
radiation therapy
adaptive radiation therapy
030218 nuclear medicine & medical imaging
predictive factor
Young Adult
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
Regular Paper
medicine
Carcinoma
Humans
Radiology, Nuclear Medicine and imaging
Lymph node
Survival analysis
Aged
Aged, 80 and over
Univariate analysis
Nasopharyngeal Carcinoma
Radiation
lymph node metastasis
business.industry
Nasopharyngeal Neoplasms
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Survival Analysis
Radiation therapy
medicine.anatomical_structure
Nasopharyngeal carcinoma
030220 oncology & carcinogenesis
Predictive value of tests
Multivariate Analysis
Female
tailored therapy
Nuclear medicine
business
Subjects
Details
- ISSN :
- 13499157 and 04493060
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- Journal of Radiation Research
- Accession number :
- edsair.doi.dedup.....6cba45763d418a0d01295a3a842126aa