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A Structural Landscape of Neutralizing Antibodies Against SARS-CoV-2 Receptor Binding Domain
- Source :
- Frontiers in Immunology, Frontiers in Immunology, Vol 12 (2021)
- Publication Year :
- 2020
-
Abstract
- SARS-CoV-2, the novel coronavirus responsible for the ongoing COVID-19 pandemic, has been spreading rampantly. The global scientific community has responded rapidly to understand immune correlates of protection to develop vaccines and immunotherapeutics against the virus. The major goal of this mini review is to summarize current understanding of the structural landscape of neutralizing antibodies (nAbs) that target the receptor binding domain (RBD) of viral spike (S) glycoprotein. The RBD plays a critical role in the very first step of the virus life cycle. Better understanding of where and how nAbs bind the RBD should enable identification of sites of vulnerability and facilitate better vaccine design and formulation of immunotherapeutics. Towards this goal, we compiled 38 RBD-binding nAbs with known structures. Review of these nAb structures showed that (1) nAbs can be divided into five general clusters, (2) there are distinct non-neutralizing faces on the RBD, and (3) maximum of potentially four nAbs could bind the RBD simultaneously. Since most of these nAbs were isolated from virus-infected patients, additional analyses of vaccine-induced nAbs could facilitate development of improved vaccines.
- Subjects :
- 0301 basic medicine
COVID-19 Vaccines
Coronavirus disease 2019 (COVID-19)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Mini Review
Immunology
medicine.disease_cause
Antibodies, Viral
Virus
RBD
03 medical and health sciences
Epitopes
Structure-Activity Relationship
0302 clinical medicine
Viral life cycle
medicine
Immunology and Allergy
Humans
Neutralizing antibody
Pandemics
Coronavirus
chemistry.chemical_classification
Binding Sites
biology
SARS-CoV-2
neutralizing antibody
COVID-19
RC581-607
Virology
Antibodies, Neutralizing
neutralizing epitope
030104 developmental biology
chemistry
Spike Glycoprotein, Coronavirus
biology.protein
Immunologic diseases. Allergy
Antibody
Glycoprotein
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 16643224
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Frontiers in immunology
- Accession number :
- edsair.doi.dedup.....6cb40654a47b794f8624098b8f5e9121