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Amplification of CCND1, EMS1, PIK3CA, and ERBB Oncogenes in Ethmoid Sinus Adenocarcinomas
- Source :
- Otolaryngology–Head and Neck Surgery. 135:135-139
- Publication Year :
- 2006
- Publisher :
- Wiley, 2006.
-
Abstract
- OBJECTIVE: Assess the amplification of CCND1, EMS1, PIK3CA, ERBB1, and ERBB2 oncogenes in ethmoid sinus adenocarcinomas.STUDY DESIGN AND SETTING: Tissue samples from 13 primary ethmoid adenocarcinomas and 2 recurrences were studied at Hospital Central de Asturias, Oviedo, Spain, between July 1998 and February 2002. A semiquantitative evaluation of CCND1, EMS1, PIK3CA, ERBB1, and ERBB2 amplification was performed by multiplex polymerase chain reaction.RESULTS: Three (23%) cases presented CCND1 amplification, one of them with a concurrent PIK3CA amplification. EMS1 was amplified in the 2 studied recurrences. ERBB1 was amplified in 1 case (8%), whereas none presented ERBB2 amplification. Oncogenic amplifications were only detected in advanced (stage III) tumors; however, no prognostic value could be shown for them.CONCLUSIONS: CCND1, EMS1, PIK3CA, and ERBB1 amplifications are uncommon and appear to be late events in the development of ethmoid sinus adenocarcinoma.SIGNIFICANCE: New information on the carcinog...
- Subjects :
- Male
Paranasal Sinus Neoplasm
Pathology
medicine.medical_specialty
Class I Phosphatidylinositol 3-Kinases
Adenocarcinoma
In Vitro Techniques
Polymerase Chain Reaction
law.invention
Phosphatidylinositol 3-Kinases
03 medical and health sciences
0302 clinical medicine
Cyclin D1
Ethmoid Sinus
Ethmoid sinus
ErbB
law
Biomarkers, Tumor
medicine
Humans
Stage (cooking)
skin and connective tissue diseases
030223 otorhinolaryngology
neoplasms
Polymerase chain reaction
Aged
business.industry
DNA, Neoplasm
Genes, erbB-1
Middle Aged
medicine.disease
Gene Expression Regulation, Neoplastic
ERBB2 Amplification
medicine.anatomical_structure
Otorhinolaryngology
030220 oncology & carcinogenesis
Surgery
business
Cortactin
Paranasal Sinus Neoplasms
Subjects
Details
- ISSN :
- 10976817 and 01945998
- Volume :
- 135
- Database :
- OpenAIRE
- Journal :
- Otolaryngology–Head and Neck Surgery
- Accession number :
- edsair.doi.dedup.....6cad52dc657aa8742939b92e36c87229