Back to Search
Start Over
miRNA-26b downregulation in peripheral blood mononuclear cells of patients with hepatitis C associated lymphomas is restored by successful interferon-free antiviral therapy
- Source :
- Antiviral therapy. 24(6)
- Publication Year :
- 2019
-
Abstract
- Background Patients with chronic HCV infection are at increased risk of developing B-cell non-Hodgkin lymphoma (B-NHL). Regression of HCV-associated B-NHL (HCV-NHL) can be achieved through HCV eradication using interferon (IFN). However, only about two-thirds of patients with sustained virological response (SVR) also had a consecutive lymphoma response. miRNA-26b is associated with HCV-NHL response to antiviral therapy. Recent data suggest that IFN-free direct-acting antiviral (DAA) regimens also have anti-lymphoma activity in this patient population. Methods We report four patients with HCV-NHL who were treated with different IFN-free DAA regimens as oncological monotherapy in our centre between 2015 and 2016. We analysed the virological and lymphoproliferative disease response. Moreover, we analysed miRNA-26b expression in peripheral blood mononuclear cells at different time points during antiviral therapy for all included patients as well as for a total of 10 controls with ( n=5) and without ( n=5) chronic HCV infection. Results All patients had marginal zone lymphoma subtype and received different DAA regimens for 12–24 weeks. All four patients achieved SVR, but only three patients also had lymphoma response (one complete response, two partial responses). One patient showed progression to a high-grade lymphoma subtype after SVR. miRNA-26b expression was generally decreased in patients with HCV-NHL. Moreover, miRNA-26b expression was restored in those HCV-NHL patients with lymphoma response after 6 months ( P=0.009). Conclusions We have demonstrated that IFN-free DAA treatment of HCV can improve or even cure NHL. miRNA-26b-levels could be a potentially useful biomarker to predict lymphoma response in HCV-NHL patients.
- Subjects :
- Male
medicine.medical_specialty
Lymphoma
Sustained Virologic Response
Hepacivirus
Gastroenterology
Peripheral blood mononuclear cell
Antiviral Agents
immune system diseases
Interferon
hemic and lymphatic diseases
Internal medicine
Antiretroviral Therapy, Highly Active
medicine
Humans
Pharmacology (medical)
Aged
Retrospective Studies
Pharmacology
biology
business.industry
Retrospective cohort study
Hepatitis C
Middle Aged
Viral Load
medicine.disease
biology.organism_classification
MicroRNAs
Infectious Diseases
Treatment Outcome
Gene Expression Regulation
Leukocytes, Mononuclear
Biomarker (medicine)
Female
business
Viral load
medicine.drug
Subjects
Details
- ISSN :
- 20402058
- Volume :
- 24
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Antiviral therapy
- Accession number :
- edsair.doi.dedup.....6cac1d19cbd61b90251fdbc396465691