Back to Search
Start Over
Modified asymmetric Strecker reaction of aldehyde with secondary amine: a protocol for the synthesis of S-clopidogrel (an antiplatelet agent)
- Source :
- The Journal of organic chemistry. 77(16)
- Publication Year :
- 2012
-
Abstract
- A first approach for catalytic asymmetric Strecker reaction of aldehydes with a secondary amine in the presence of sodium fluoride using hydroquinine as chiral catalyst was developed. The catalytic system gave α-aminonitriles in excellent yields (up to 95%) and high enantioselectivities (er up to 94:6). The efficacy of the chiral product was successfully fulfilled in the improved synthesis of (S)-clopidogrel (an antiplatelet agent).
- Subjects :
- inorganic chemicals
Magnetic Resonance Spectroscopy
Ticlopidine
Strecker amino acid synthesis
Aldehyde
Catalysis
chemistry.chemical_compound
Sodium fluoride
medicine
Organic chemistry
heterocyclic compounds
Amines
chemistry.chemical_classification
Aldehydes
Molecular Structure
Chemistry
organic chemicals
Organic Chemistry
Stereoisomerism
Clopidogrel
Quinidine
Sodium Fluoride
Amine gas treating
Platelet Aggregation Inhibitors
medicine.drug
Subjects
Details
- ISSN :
- 15206904
- Volume :
- 77
- Issue :
- 16
- Database :
- OpenAIRE
- Journal :
- The Journal of organic chemistry
- Accession number :
- edsair.doi.dedup.....6caa7c3645ffbb50b4e6aebda178c7b0