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Three-day CSF drainage barely reduces ventricular size in normal pressure hydrocephalus
- Source :
- Neurology. 79:237-242
- Publication Year :
- 2012
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2012.
-
Abstract
- External lumbar drainage (ELD) of CSF is a test to determine the suitability of a shunt for patients with normal pressure hydrocephalus (NPH), but its effect on ventricular volume is not known. This study investigates the effect of 3-day ELD of 500 mL on ventricular size and clinical features in patients with idiopathic NPH.Fifteen patients were investigated in a 1.5-T MRI scanner before and after ELD. Ventricular volume was measured manually. Clinical features involved motor and cognitive functions, testing primarily gait and attention. Reduction in ventricular volume was correlated to total drain volume and clinical parameters. Statistical tests were nonparametric, and p0.05 was required for significance.Drain volume was 415 mL (median 470 mL, range 160-510 mL). Ventricular size was reduced in all patients, averaging 3.7 mL (SD 2.2 mL, p0.001), which corresponded to a 4.2% contraction. The ratio of volume contraction to drain volume was only 0.9%. Seven patients improved in gait and 6 in attention. Ventricular reduction and total drain volume correlated neither with improvement nor with each other. The 7 patients with the largest drain volumes (close to 500 mL), had ventricular changes varying from 1.3 to 7.5 mL.Clinical improvement occurs in patients with NPH after ELD despite unaltered ventricles, suggesting that ventricular size is of little relevance for postshunt improvement or determining shunt function. The clinical effect provided by ELD, mimicking shunting, is probably related to the recurring CSF extractions rather than to the cumulative effect of the drainage on ventricular volume.
- Subjects :
- Male
Walking
Neuropsychological Tests
Ventriculoperitoneal Shunt
Catheterization
Cerebral Ventricles
Lumbar
Normal pressure hydrocephalus
Image Processing, Computer-Assisted
medicine
Humans
Whole Body Imaging
Drainage
Gait
Aged
Aged, 80 and over
medicine.diagnostic_test
Ventricular size
business.industry
Magnetic resonance imaging
Csf drainage
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Hydrocephalus, Normal Pressure
Hydrocephalus
Anesthesia
Female
Neurology (clinical)
business
Shunt (electrical)
Subjects
Details
- ISSN :
- 1526632X and 00283878
- Volume :
- 79
- Database :
- OpenAIRE
- Journal :
- Neurology
- Accession number :
- edsair.doi.dedup.....6ca6be2cec41ea838823acc31b2d1eb5