Back to Search
Start Over
Lower copy numbers of the chemokine CCL3L1 gene in patients with chronic hepatitis C
- Source :
- Journal of hepatology. 52(2)
- Publication Year :
- 2009
-
Abstract
- Recently, variation of gene copy numbers was recognized as a novel type of common genetic diversity, but its impact on viral hepatitis is unknown. Here, we determine the influence of copy number variation on the susceptibility and disease severity in hepatitis C virus (HCV) infection, investigating copy number variants (CNVs) of the chemokine CCL3L1 gene, which encodes a potent CCR5 ligand.CNVs were determined in 254 patients with chronic hepatitis C, 144 HCV/HIV co-infected patients, and 210 HCV negative controls, using quality-controlled real-time fluorescent dye-labeled quantitative PCR. Liver biopsies were obtained from HCV infected patients.Copy numbers of the CCL3L1 gene range from 0 to 12 (mean 2.7+/-1.4 copies). Patients with two or less copies are over-represented in the HCV infected cohort compared to HCV negative controls (odds ratio [OR] 1.54; p=0.02). CCL3L1 copies are shifted to lower numbers in HCV infected patients (means 2.6 vs. 2.9 in controls; p=0.011). HCV/HIV co-infected patients carry even lower CCL3L1 copy numbers compared to controls (means 2.2 vs. 2.9; p0.001), with a higher proportion of patients possessing two or less copies (OR=3.42; p0.001). No association was detected between CCL3L1 copy numbers and histological grades of inflammation or stages of fibrosis.Lower CCL3L1 gene copy number compared to the population median is associated with chronic hepatitis C. Copy number variation of host genes represents a novel class of genetic diversity associated with viral hepatitis.
- Subjects :
- Adult
Male
Adolescent
Receptors, CCR5
Hepatitis C virus
Hepacivirus
Gene Dosage
HIV Infections
medicine.disease_cause
Virus
Young Adult
T-Lymphocyte Subsets
medicine
Humans
Genetic Predisposition to Disease
Copy-number variation
CCL3L1
Aged
Hepatitis B virus
Aged, 80 and over
Hepatology
biology
Genetic Variation
Hepatitis C
Hepatitis C, Chronic
Middle Aged
biology.organism_classification
medicine.disease
Virology
Case-Control Studies
Chemokines, CC
Immunology
Female
Viral hepatitis
Chromosomes, Human, Pair 17
Subjects
Details
- ISSN :
- 16000641
- Volume :
- 52
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of hepatology
- Accession number :
- edsair.doi.dedup.....6c99f9bf2fd636c308756196bd5cb775