Back to Search
Start Over
Orthostatic hypotension is differentially associated with the cerebellar versus the parkinsonian variant of multiple system atrophy: a comparative study
- Source :
- Cerebellum (London, England). 11(1)
- Publication Year :
- 2011
-
Abstract
- Orthostatic hypotension (OH) is a cardinal feature of autonomic failure in multiple system atrophy (MSA); however, there are few comparative data on OH in the motor subtypes of MSA. In the present retrospective study, postural blood pressure drop after 3 min of standing was determined in 16 patients with the cerebellar variant of MSA (MSA-C) and in 17 patients with the Parkinson variant (MSA-P). Twenty idiopathic Parkinson’s disease (IPD) patients matched for age, sex, disease duration and dopaminergic therapy served as control group. OH frequency and severity were more pronounced in MSA-C followed by MSA-P and IPD. Differences in brainstem pathology are likely to account for the tight association of MSA-C and OH. A simple standing test should be obligatory in the work-up of patients with sporadic late-onset ataxias.
- Subjects :
- Adult
Male
medicine.medical_specialty
Neurology
Parkinson's disease
Shy-Drager Syndrome
Diagnosis, Differential
Orthostatic vital signs
Atrophy
stomatognathic system
Parkinsonian Disorders
Cerebellar Diseases
Internal medicine
parasitic diseases
mental disorders
medicine
Humans
Pure autonomic failure
Aged
Retrospective Studies
Dopaminergic
Genetic Variation
Retrospective cohort study
Parkinson Disease
Middle Aged
Multiple System Atrophy
medicine.disease
nervous system diseases
nervous system
Anesthesia
Cardiology
Female
Neurology (clinical)
Brainstem
Psychology
Subjects
Details
- ISSN :
- 14734230
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Cerebellum (London, England)
- Accession number :
- edsair.doi.dedup.....6c791f3c3d1d5cc1959925808e25cfac