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Association of Physical Activity with the Risk of Hepatocellular Carcinoma in Patients with Chronic Hepatitis B
- Source :
- Cancers, Volume 13, Issue 14, Cancers, Vol 13, Iss 3424, p 3424 (2021)
- Publication Year :
- 2021
-
Abstract
- Background and Aims: In the general population, previous studies reported that physical activity was associated with risk of hepatocellular carcinoma (HCC) development. However, it is unclear whether physical activity is associated with risk of HCC development in patients with chronic hepatitis B (CHB). We aimed to elucidate the association between physical activity and risk of HCC development in CHB patients. Methods: This nationwide cohort study involved treatment-naive patients with CHB (n = 9727) who started treatment with entecavir or tenofovir and answered self-reported questionnaires between January 2012 and December 2017, using data from the Korean National Health Insurance Service database. The primary endpoint was development of HCC. Multivariable Cox regression and competing risk analyses were used. Results: During a median follow-up of 3.1 years, cumulative HCC incidence rates were 8.3%. There was an inverse association between physical activity and the risk of HCC (p &lt<br />0.001). Patients with 1000–1500 metabolic equivalent task (MET)-min/week, compared to those without physical activity, showed a significantly lower risk of HCC in both patients without cirrhosis (adjusted hazard ratio [aHR] 0.66, p = 0.02) and patients with cirrhosis (aHR 0.61, p = 0.02). In patients who were younger (&lt<br />60), male, without diabetes, and with high BMI, amounts of physical activity of 1000–1500 MET-min/week showed an inverse association with the risk of HCC (aHR 0.65, 0.63, 0.65, and 0.64, respectively, all p &lt<br />0.05). Conclusion: Physical activity was significantly associated with a low risk of HCC in CHB patients treated with entecavir or tenofovir.
- Subjects :
- Cancer Research
medicine.medical_specialty
Population
physical activity
Lower risk
Gastroenterology
Metabolic equivalent
Article
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
chronic hepatitis B
education
RC254-282
education.field_of_study
Proportional hazards model
business.industry
Hazard ratio
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Entecavir
hepatocellular carcinoma
medicine.disease
digestive system diseases
Oncology
030220 oncology & carcinogenesis
Hepatocellular carcinoma
030211 gastroenterology & hepatology
business
medicine.drug
Cohort study
Subjects
Details
- ISSN :
- 20726694
- Volume :
- 13
- Issue :
- 14
- Database :
- OpenAIRE
- Journal :
- Cancers
- Accession number :
- edsair.doi.dedup.....6c60e90bb990ccc864cb9bc6f837f999