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Long-term survival after intensive chemotherapy or hypomethylating agents in AML patients aged 70 years and older: a large patient data set study from European registries
- Source :
- Leukemia, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe, instname, LEUKEMIA, r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
- Publication Year :
- 2022
- Publisher :
- NATURE PUBLISHING GROUP, 2022.
-
Abstract
- The outcome of acute myeloid leukemia patients aged 70 years or older is poor. Defining the best treatment option remains controversial especially when choosing between intensive chemotherapy and hypomethylating agents. We set up a multicentric European database collecting data of 3 700 newly diagnosed acute myeloid leukemia patients ≥70 years. The primary objective was to compare overall survival in patients selected for intensive chemotherapy (n = 1199) or hypomethylating agents (n = 1073). With a median follow-up of 49.5 months, the median overall survival was 10.9 (95% CI: 9.7–11.6) and 9.2 months (95% CI: 8.3–10.2) with chemotherapy and hypomethylating agents, respectively. Complete remission or complete remission with incomplete hematologic recovery was 56.1% and 19.7% with chemotherapy and hypomethylating agents, respectively (P
- Subjects :
- Cancer Research
medicine.medical_specialty
medicine.medical_treatment
EARLY DEATH
NEWLY-DIAGNOSED AML
Intensive chemotherapy
ACUTE MYELOID-LEUKEMIA
REGIMENS
Lower risk
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
Long term survival
MANAGEMENT
Humans
Medicine
In patient
VENETOCLAX
Registries
ELDERLY-PATIENTS
AZACITIDINE
Aged
Aged, 80 and over
Chemotherapy
EPIGENETIC THERAPY
business.industry
Significant difference
Myeloid leukemia
Hematology
Patient data
CARE
Leukemia, Myeloid, Acute
Treatment Outcome
Oncology
Azacitidine
business
Subjects
Details
- ISSN :
- 08876924
- Database :
- OpenAIRE
- Journal :
- Leukemia, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe, instname, LEUKEMIA, r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
- Accession number :
- edsair.doi.dedup.....6c4fd2308cc3bead0a723ebfdc6b70e7