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Clinical Analysis of 21 Cases of Nongestational Ovarian Choriocarcinoma
- Source :
- International Journal of Gynecological Cancer. 20:299-302
- Publication Year :
- 2010
- Publisher :
- BMJ, 2010.
-
Abstract
- Introduction: The objective of the study was to investigate the clinical characters, diagnosis, treatment, and prognosis of nongestational ovarian choriocarcinoma. Methods: A retrospective analysis was done on 21 patients with nongestational ovarian choriocarcinoma treated in Peking Union Medical College Hospital from January 1985 to October 2008. All patients9 conditions were diagnosed by histopathologic examination; in 3 of them, the diagnosis was confirmed by DNA polymorphism analysis at 12 short tandem repeat loci. Results: Correct diagnosis was achieved in only 3 patients before initial treatment. All patients received standard multiple-drug combined chemotherapy and underwent an operation. The mean number of chemotherapy courses for each patient was 10. Of the 21 patients, 16 achieved complete remission, and 4 obtained partial remission; 1 died. In a median follow-up of 71.4 months, the 5-year overall survival rate was 79.4%. Conclusions: The early diagnosis of nongestational ovarian choriocarcinoma is expected to be improved. DNA polymorphism analysis is a useful tool in determining the origin of ovarian choriocarcinoma. The prognosis is optimistic if managed with standard multiple-drug chemotherapy combined with surgical treatment.
- Subjects :
- Adult
Oncology
China
medicine.medical_specialty
Adolescent
medicine.medical_treatment
Ovarian Choriocarcinoma
Young Adult
Text mining
Internal medicine
medicine
Humans
Initial treatment
Child
Surgical treatment
Retrospective Studies
Ovarian Neoplasms
Chemotherapy
Clinical pathology
business.industry
Choriocarcinoma, Non-gestational
Complete remission
Obstetrics and Gynecology
Combination chemotherapy
Middle Aged
female genital diseases and pregnancy complications
Treatment Outcome
Female
business
Subjects
Details
- ISSN :
- 1048891X
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- International Journal of Gynecological Cancer
- Accession number :
- edsair.doi.dedup.....6c4a9399f0e18eccfea798728f5e42b6