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A Randomized Clinical Trial of Greek High Phenolic Early Harvest Extra Virgin Olive Oil in Mild Cognitive Impairment: The MICOIL Pilot Study
- Source :
- Journal of Alzheimer's Disease. 78:801-817
- Publication Year :
- 2020
- Publisher :
- IOS Press, 2020.
-
Abstract
- Background: Extra virgin olive oil (EVOO) constitutes a natural compound with high protection over cognitive function. Objective: To investigate for the first time the effect of Greek High Phenolic Early Harvest Extra Virgin Olive Oil (HP-EH-EVOO) versus Moderate Phenolic (MP-EVOO) and Mediterranean Diet (MeDi) in people with mild cognitive impairment (MCI). Methods: We conducted a randomized prospective study so as to examine the HP-EH-EVOO and MP-EVOO versus MeDi in MCI. Genetic predisposition (APOE ɛ4) to Alzheimer’s disease (AD) was tested and an extensive neuropsychological battery was administered at baseline and after 12 months. Each participant was randomized and assigned one of three groups: 1) Group 1 received the HP-EH-EVOO (50 mL/day); 2) Group 2 received the MP-EVOO (50 mL/day), and 3) Group 3 received only the MeDi instructions. Results: Better follow-up performance was found in Group 1 compared to Group 2 and Group 3 in the almost all cognitive domains. Moreover, Group 2 showed also significant improvement compared to Group 3 in ADAS-cog (p = 0.001) and MMSE (p = 0.05), whereas Group 3 exhibited worse or similar to baseline performance in almost all domains. In particular, Group 1 and Group 2 had better outcomes with regards to ADAS-cog (p = 0.003), Digit Span (p = 0.006), and Letter fluency (p = 0.003). Moreover, there was a significant difference (p = 0.001) in the presence of APOE ɛ4 between the Groups 1 and 2 versus Group 3. Conclusion: Long-term intervention with HP-EH-EVOO or MP-EVOO was associated with significant improvement in cognitive function compared to MeDi, independent of the presence of APOE ɛ4.
- Subjects :
- Male
medicine.medical_specialty
Magnetic Resonance Spectroscopy
Mediterranean diet
Pilot Projects
Neuropsychological Tests
Diet, Mediterranean
law.invention
Cohort Studies
Double-Blind Method
Phenols
Randomized controlled trial
law
Internal medicine
Memory span
medicine
Genetic predisposition
Humans
Cognitive Dysfunction
Longitudinal Studies
Prospective Studies
Prospective cohort study
Cognitive impairment
Olive Oil
Aged
Aged, 80 and over
Greece
business.industry
General Neuroscience
Cognition
General Medicine
Middle Aged
Psychiatry and Mental health
Clinical Psychology
Female
Geriatrics and Gerontology
business
Olive oil
Subjects
Details
- ISSN :
- 18758908 and 13872877
- Volume :
- 78
- Database :
- OpenAIRE
- Journal :
- Journal of Alzheimer's Disease
- Accession number :
- edsair.doi.dedup.....6c45b38962378904d157c613fda68f04