An improved synthesis of carbon-11 labeled acetoacetic acid and an evaluation of its potential for the investigation of cerebral pathology by positron emission tomography

Authors :: W Vaalburg
G. H. M. Prenen
Anne M. J. Paans
K.G. Go
F. Zuiderveen
Source :: International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes. 41:1209-1216
Publication Year :: 1990
Publisher :: Elsevier BV, 1990.
Abstract: 1-11C-acetoacetic acid was synthesized by carboxylation of the acetone carbanion. Purification was carried out using HPLC. The product was obtained with a radiochemical yield of up to 58%, corrected for decay, in a total preparation time of 30 min. The distribution of 1-11C-acetoacetic acid after injection into adult Wistar rats and cats was investigated by PET. When the tracer was injected into cats, 3 weeks after inflicting a unilateral freezing lesion upon the brain, accumulation of 1-11C-acetoacetic acid in the ipsilateral brain hemisphere was observed.

ISSN :: 08832889
Volume :: 41
Database :: OpenAIRE
Journal :: International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes
Accession number :: edsair.doi.dedup.....6c4268c6b31aac45713871f16770cbb3
Full Text :: https://doi.org/10.1016/0883-2889(90)90208-x

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