Association Analysis of the FTO Gene with Obesity in Children of Caucasian and African Ancestry Reveals a Common Tagging SNP

Authors :: Julie L. Shaner
Robert I. Berkowitz
F. George Otieno
Rosetta M. Chiavacci
Ryan M. Smith
Jonathan P. Bradfield
Marcin Imielinski
Cecilia E. Kim
Hakon Hakonarson
Erin Santa
Joseph T. Glessner
Edward C. Frackelton
Mingyao Li
Struan F.A. Grant
Tracy Casalunovo
Kiran Annaiah
Andrew W. Eckert
Source :: PLoS ONE, PLoS ONE, Vol 3, Iss 3, p e1746 (2008)
Publication Year :: 2008
Publisher :: Public Library of Science (PLoS), 2008.
Abstract: Recently an association was demonstrated between the single nucleotide polymorphism (SNP), rs9939609, within the FTO locus and obesity as a consequence of a genome wide association (GWA) study of type 2 diabetes in adults. We examined the effects of two perfect surrogates for this SNP plus 11 other SNPs at this locus with respect to our childhood obesity cohort, consisting of both Caucasians and African Americans (AA). Utilizing data from our ongoing GWA study in our cohort of 418 Caucasian obese children (BMI>or=95th percentile), 2,270 Caucasian controls (BMI

Full Text Access

Tools