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Cytotoxic T Lymphocyte Antigen-4 Accumulation in the Immunological Synapse Is Regulated by TCR Signal Strength
- Source :
- Immunity. 16:23-35
- Publication Year :
- 2002
- Publisher :
- Elsevier BV, 2002.
-
Abstract
- CD28 and CTLA-4 engagement with B7 expressed by APCs generates critical regulatory signals for T cell activation. CD28 is expressed on the T cell surface and enhances T cell expansion, while CTLA-4 localizes primarily to an intracellular compartment and inhibits T cell proliferation. We demonstrate that CTLA-4 has several unique trafficking properties that may regulate its ability to attenuate a T cell response. Importantly, accumulation of CTLA-4 at the immunological synapse is proportional to the strength of the TCR signal, suggesting that cells receiving stronger stimuli are more susceptible to CTLA-4-mediated inhibition. This may represent a novel feedback control mechanism in which a stimulatory signal regulates the recruitment of an inhibitory receptor to a functionally relevant site on the cell surface.
- Subjects :
- Cell signaling
Immunoconjugates
T-Lymphocytes
T cell
Molecular Sequence Data
Immunology
Receptors, Antigen, T-Cell
Antigen-Presenting Cells
Mice, Transgenic
chemical and pharmacologic phenomena
Cell Communication
Biology
Lymphocyte Activation
Immunological synapse
Abatacept
Mice
CD28 Antigens
Antigens, CD
medicine
Animals
Immunology and Allergy
Cytotoxic T cell
CTLA-4 Antigen
Amino Acid Sequence
Antigen-presenting cell
Cells, Cultured
T-cell receptor
CD28
Biological Transport
hemic and immune systems
Antigens, Differentiation
Cell biology
Infectious Diseases
medicine.anatomical_structure
Synapses
Interleukin-2
Intracellular
Subjects
Details
- ISSN :
- 10747613
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Immunity
- Accession number :
- edsair.doi.dedup.....6c296d2fbfc8f22b22e9f4b9eac8876d