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Discovery of novel polyamide-pyrrolobenzodiazepine hybrids for antibody-drug conjugates
- Source :
- Bioorganic & Medicinal Chemistry Letters. 72:128876
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- Pyrrolobenzodiazepine (PBD) dimers are well-known highly potent antibody drug conjugate (ADC) payloads. The corresponding PBD monomers, in contrast, have received much less attention from the ADC community. We prepared several novel polyamide-linked PBD monomers and evaluated their utility as ADC payloads. The unconjugated polyamide-PBD hybrids exhibited potent antiproliferative activity (IC50 range: 10
Details
- ISSN :
- 0960894X
- Volume :
- 72
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....6c28732d20f05570a4c9c7504b2fae53
- Full Text :
- https://doi.org/10.1016/j.bmcl.2022.128876