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qFibrosis: A fully-quantitative innovative method incorporating histological features to facilitate accurate fibrosis scoring in animal model and chronic hepatitis B patients
- Source :
- Journal of Hepatology. 61(2):260-269
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Background & Aims: There is increasing need for accurate assessment of liver fibrosis/cirrhosis. We aimed to develop qFibrosis, a fully-automated assessment method combining quantification of histopathological architectural features, to address unmet needs in core biopsy evaluation of fibrosis in chronic hepatitis B (CHB) patients.Methods: qFibrosis was established as a combined index based on 87 parameters of architectural features. Images acquired from 25 Thioacetamide-treated rat samples and 162 CHB core biopsies were used to train and test qFibrosis and to demonstrate its reproducibility. qFibrosis scoring was analyzed employing Metavir and Ishak fibrosis staging as standard references, and collagen proportionate area (CPA) measurement for comparison. Results: qFibrosis faithfully and reliably recapitulates Metavir fibrosis scores, as it can identify differences between all stages in both animal samples (p
- Subjects :
- medicine.medical_specialty
Pathology
Cirrhosis
Biopsy
Liver Cirrhosis, Experimental
Chronic liver disease
Gastroenterology
Chronic hepatitis B
Image analysis
Hepatitis B, Chronic
Fibrosis
Internal medicine
medicine
qFibrosis
Animals
Humans
Liver fibrosis assessment
medicine.diagnostic_test
Receiver operating characteristic
Hepatology
business.industry
Hepatitis B
Liver biopsy
medicine.disease
Rats
Disease Models, Animal
Liver
Collagen
business
Hepatic fibrosis
Subjects
Details
- ISSN :
- 01688278
- Volume :
- 61
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of Hepatology
- Accession number :
- edsair.doi.dedup.....6c25acd3b44eb111bf3f9a4e09a3e0fb
- Full Text :
- https://doi.org/10.1016/j.jhep.2014.02.015