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In vitro studies with bendamustine: Enhanced activity in combination with rituximab
- Source :
- Seminars in Oncology. 29:12-14
- Publication Year :
- 2002
- Publisher :
- Elsevier BV, 2002.
-
Abstract
- Studies in vitro have shown that bendamustine, given as a monotherapy or in combination, can induce apoptosis in many cell types, including B-cell chronic lymphocytic leukemia and low-grade lymphoma cells. Evidence is accumulating to suggest that bendamustine may also have synergistic effects in combination therapies. Rituximab is a promising new agent for the treatment of hematologic malignancies and has been shown to have synergistic actions with other chemotherapeutic agents. The actions of the combination of bendamustine and rituximab on ex vivo B-cell chronic lymphocytic leukemia cells and the DOHH-2 cell line, derived from CD20-positive lymphoma cells, are discussed in this article.
- Subjects :
- Bendamustine
Chronic lymphocytic leukemia
Antineoplastic Agents
Apoptosis
Antibodies, Monoclonal, Murine-Derived
chemistry.chemical_compound
immune system diseases
hemic and lymphatic diseases
Antineoplastic Combined Chemotherapy Protocols
Tumor Cells, Cultured
Bendamustine Hydrochloride
Humans
Medicine
business.industry
Lymphoma, Non-Hodgkin
Carcinoma
Antibodies, Monoclonal
Drug Synergism
Complement System Proteins
Hematology
Antigens, CD20
medicine.disease
Leukemia, Lymphocytic, Chronic, B-Cell
Nitrogen mustard
Lymphoma
Leukemia
chemistry
Oncology
Nitrogen Mustard Compounds
Immunology
Monoclonal
Cancer research
Rituximab
business
Ex vivo
medicine.drug
Subjects
Details
- ISSN :
- 00937754
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Seminars in Oncology
- Accession number :
- edsair.doi.dedup.....6c256b8d8d21d8a29503c50c41c5a943