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Associations of atrophic gastritis and proton-pump inhibitor drug use with vitamin B-12 status, and the impact of fortified foods, in older adults
- Source :
- The American Journal of Clinical Nutrition
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Background Atrophic gastritis (AG) and use of proton pump inhibitors (PPIs) result in gastric acid suppression that can impair the absorption of vitamin B-12 from foods. The crystalline vitamin B-12 form, found in fortified foods, does not require gastric acid for its absorption and could thus be beneficial for older adults with hypochlorhydria, but evidence is lacking. Objectives To investigate associations of AG and PPI use with vitamin B-12 status, and the potential protective role of fortified foods, in older adults. Methods Eligible participants (n = 3299) not using vitamin B-12 supplements were drawn from the Trinity-Ulster and Department of Agriculture cohort, a study of noninstitutionalized adults aged ≥60 y and recruited in 2008–2012. Vitamin B-12 status was measured using 4 biomarkers, and vitamin B-12 deficiency was defined as a combined indicator value
- Subjects :
- Gastritis, Atrophic
Male
Drug
Vitamin
Aging
medicine.medical_specialty
Atrophic gastritis
medicine.drug_class
media_common.quotation_subject
Nutritional Status
Medicine (miscellaneous)
Proton-pump inhibitor
proton pump inhibitor drugs
Gastroenterology
AcademicSubjects/MED00160
AcademicSubjects/MED00060
chemistry.chemical_compound
food-bound malabsorption
atrophic gastritis
Internal medicine
Prevalence
medicine
Humans
Vitamin B12
Fortified Food
older adults
Aged
fortified foods
media_common
Nutrition and Dietetics
Pepsinogens
business.industry
Achlorhydria
hypochlorhydria
Proton Pump Inhibitors
Vitamin B 12 Deficiency
medicine.disease
Vitamin B 12
Original Research Communications
chemistry
Food, Fortified
Vitamin B Complex
Cohort
vitamin B-12 biomarkers
Gastric acid
Female
business
Biomarkers
Subjects
Details
- ISSN :
- 00029165
- Volume :
- 114
- Database :
- OpenAIRE
- Journal :
- The American Journal of Clinical Nutrition
- Accession number :
- edsair.doi.dedup.....6c24353b2bbb6ca38b1aa8d26f4e6817