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A polyvalent coral snake antivenom with broad neutralization capacity
- Source :
- PLoS Neglected Tropical Diseases, Vol 13, Iss 3, p e0007250 (2019), PLoS Neglected Tropical Diseases
- Publication Year :
- 2019
- Publisher :
- Public Library of Science (PLoS), 2019.
-
Abstract
- Coral snakes of the genus Micrurus have a high diversity and wide distribution in the Americas. Despite envenomings by these animals being uncommon, accidents are often severe and may result in death. Producing an antivenom to treat these envenomings has been challenging since coral snakes are difficult to catch, produce small amounts of venom, and the antivenoms produced have shown limited cross neutralization. Here we present data of cross neutralization among monovalent antivenoms raised against M. dumerilii, M. isozonus, M. mipartitus and M. surinamensis and the development of a new polyvalent coral snake antivenom, resulting from the mix of monovalent antivenoms. Our results, show that this coral snake antivenom has high neutralizing potency and wide taxonomic coverage, constituting a possible alternative for a long sought Pan-American coral snake antivenom.<br />Author summary Coral snakes are distributed in the Americas form Southern United States to Argentina. These snakes cause envenomings that, despite not being common, often lead to death. The antivenoms currently produced to treat accidents caused by these snakes have limitations regarding the number of species venoms they could neutralize. Here, we present an antivenom with a wide spectrum of neutralization, when compared to other Anticoral antivenoms. Nevertheless, more studies are still necessary to evaluate its neutralization capacity against the venoms of other species. This antivenom has great potential, as it neutralizes the lethal effects of some of the most common Micrurus species in the Americas.
- Subjects :
- 0301 basic medicine
Physiology
RC955-962
Antivenom
Genus Micrurus
Venom
Toxicology
Pathology and Laboratory Medicine
Biochemistry
Neutralization
0302 clinical medicine
Intraperitoneal Injections
Immune Physiology
Arctic medicine. Tropical medicine
Medicine and Health Sciences
Toxins
Snakebite
Routes of Administration
Cross Reactivity
Mammals
Immune System Proteins
biology
Antivenins
Eukaryota
Snakes
Squamates
Infectious Diseases
Vertebrates
Public aspects of medicine
RA1-1270
Research Article
Neglected Tropical Diseases
Toxic Agents
Equines
Immunology
030231 tropical medicine
Zoology
Coral Snakes
Cross Reactions
Antibodies
03 medical and health sciences
Neutralization Tests
Cross neutralization
Animals
Immunologic Factors
Horses
Coral snake
Pharmacology
Toxicity
Venoms
Organisms
Public Health, Environmental and Occupational Health
Biology and Life Sciences
Reptiles
Proteins
Cross reactions
Tropical Diseases
biology.organism_classification
Coral Snake Antivenom
030104 developmental biology
Amniotes
Americas
Subjects
Details
- ISSN :
- 19352735
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- PLOS Neglected Tropical Diseases
- Accession number :
- edsair.doi.dedup.....6c21916b61b829fd0be614c05bc01f76