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Potential of Chemically Synthesized Oligosaccharides To Define the Carbohydrate Moieties of the Fungal Cell Wall Responsible for the Human Immune Response, Using Aspergillus fumigatus Galactomannan as a Model
- Source :
- MSphere, MSphere, 2020, 5 (1), pp.e00688-19. ⟨10.1128/mSphere.00688-19⟩, MSphere, American Society for Microbiology., 2020, 5 (1), pp.e00688-19. ⟨10.1128/mSphere.00688-19⟩, mSphere, Vol 5, Iss 1, p e00688-19 (2020), mSphere, Vol 5, Iss 1 (2020), mSphere
- Publication Year :
- 2020
- Publisher :
- HAL CCSD, 2020.
-
Abstract
- Methodologies to identify epitopes or ligands of the fungal cell wall polysaccharides influencing the immune response of human pathogens have to date been imperfect. Using the galactomannan (GM) of Aspergillus fumigatus as a model, we have shown that synthetic oligosaccharides of distinct structures representing key fragments of cell wall polysaccharides are the most precise tools to study the serological and immunomodulatory properties of a fungal polysaccharide.
- Subjects :
- 0301 basic medicine
Antigens, Fungal
[SDV]Life Sciences [q-bio]
lcsh:QR1-502
Oligosaccharides
chemokines
Polysaccharide
01 natural sciences
Microbiology
Epitope
lcsh:Microbiology
Host-Microbe Biology
Aspergillus fumigatus
Immunomodulation
Mannans
Cell wall
immunology
Epitopes
03 medical and health sciences
Galactomannan
chemistry.chemical_compound
Immune system
Cell Wall
glycoarray
Humans
antibodies
aspergillosis
skin and connective tissue diseases
Molecular Biology
[SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology
chemistry.chemical_classification
Aspergillus
biology
010405 organic chemistry
Galactose
Opinion/Hypothesis
biology.organism_classification
QR1-502
cytokines
3. Good health
0104 chemical sciences
030104 developmental biology
chemistry
Biochemistry
galactomannan
biology.protein
Antibody
Subjects
Details
- Language :
- English
- ISSN :
- 23795042
- Database :
- OpenAIRE
- Journal :
- MSphere, MSphere, 2020, 5 (1), pp.e00688-19. ⟨10.1128/mSphere.00688-19⟩, MSphere, American Society for Microbiology., 2020, 5 (1), pp.e00688-19. ⟨10.1128/mSphere.00688-19⟩, mSphere, Vol 5, Iss 1, p e00688-19 (2020), mSphere, Vol 5, Iss 1 (2020), mSphere
- Accession number :
- edsair.doi.dedup.....6c1999875e1f97d04e129856500b4a7f
- Full Text :
- https://doi.org/10.1128/mSphere.00688-19⟩