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Pilot study indicate role of preferentially transmitted monoamine oxidase gene variants in behavioral problems of male ADHD probands
- Source :
- BMC Medical Genetics, BMC Medical Genetics, Vol 18, Iss 1, Pp 1-12 (2017)
- Publication Year :
- 2017
- Publisher :
- BioMed Central, 2017.
-
Abstract
- Background Attention deficit hyperactivity disorder (ADHD) is an etiologically complex childhood onset neurobehavioral disorder characterized by age-inappropriate inattention, hyperactivity, and impulsivity. Symptom severity varies widely and boys are diagnosed more frequently than girls. ADHD probands were reported to have abnormal transmissions of dopamine, serotonin, and/or noradrenaline. Monoamine oxidase A (MAOA) and B (MAOB), mitochondrial outer membrane bound two isoenzymes, mediate degradation of these neurotransmitters and thus regulating their circulating levels. Case-control analyses in different populations, including Indians, suggested involvement of MAOA and MAOB genes in the etiology of ADHD. Due to high heritability rate of ADHD, we tested familial transmission of MAOA and MAOB variants to ADHD probands in 190 nuclear families having ADHD probands from Indo-Caucasoid ethnicity. Methods Subjects were recruited following the Diagnostic and Statistical Manual of Mental Disorders-4th edition (DSM-IV). Appropriate scales were used for measuring the behavioral traits in probands. Genotyping was performed through PCR-based amplification of target sites followed by DNA-sequencing and/or gel-electrophoresis. Data obtained were analyzed by family based statistical methods. Results Out of 58 variants present in the analyzed sites only 15 were found to be polymorphic (30 bp-uVNTR, rs5906883, rs1465107, rs1465108, rs5905809, rs5906957, rs6323, rs1137070 from MAOA and rs4824562, rs56220155, rs2283728, rs2283727, rs3027441, rs6324, rs3027440 from MAOB). Statistically significant maternal transmission of alleles to male probands was observed for MAOA rs5905809 ‘G’ (p = 0.04), rs5906957 ‘A’ (p = 0.04), rs6323 ‘G’ (p = 0.0001) and MAOB rs56220155 ‘A’ (p = 0.002), rs2283728 ‘C’ (p = 0.0008), rs2283727 ‘C’ (p = 0.0008), rs3027441 ‘T’ (p = 0.003), rs6324 ‘C’ (p = 0.003), rs3027440 ‘T’ (p = 0.0002). Significantly preferential maternal transmissions of different haplotype combinations to male probands were also noticed (p
- Subjects :
- 0301 basic medicine
Proband
Indo-Caucasoid population
Male
Linkage disequilibrium
Genotyping Techniques
Pilot Projects
0302 clinical medicine
Genetics (clinical)
Genetics
education.field_of_study
biology
Diagnostic and Statistical Manual of Mental Disorders
Female
Monoamine oxidase B
medicine.symptom
Monoamine oxidase A
Research Article
lcsh:Internal medicine
Genotyping
lcsh:QH426-470
MAOB
Population
Impulsivity
White People
03 medical and health sciences
Maternal transmission
medicine
Attention deficit hyperactivity disorder
ADHD
Humans
Genetic Predisposition to Disease
MAOA
education
lcsh:RC31-1245
Monoamine Oxidase
Alleles
Maternal age
Problem Behavior
business.industry
Haplotype
medicine.disease
lcsh:Genetics
030104 developmental biology
Haplotypes
Attention Deficit Disorder with Hyperactivity
biology.protein
business
Behavioral trait
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 14712350
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- BMC Medical Genetics
- Accession number :
- edsair.doi.dedup.....6c18054c74ba6314e99b0615538a0ffd