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Genetic alterations defining NSCLC subtypes and their therapeutic implications
- Source :
- Lung Cancer. 82:179-189
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- Lung cancer is the leading cause of cancer death worldwide, accounting for more deaths than breast, prostate and colon cancer combined. While treatment decisions are determined primarily by stage, therapeutically non small cell lung cancer (NSCLC) has traditionally been treated as a single disease. However, recent findings have led to the recognition of histology and molecular subtypes as important determinants in treatment selection. Identifying the genetic differences that define these molecular and histological subtypes has the potential to impact treatment and as such is currently the focus of much research. Microarray and genomic sequencing efforts have provided unparalleled insight into the genomes of lung cancer subtypes, specifically adenocarcinoma (AC) and squamous cell carcinoma (SqCC), revealing subtype specific genomic alterations and molecular subtypes as well as differences in cell signaling pathways. In this review, we discuss the recurrent genomic alterations characteristic of AC and SqCC (including molecular subtypes), their therapeutic implications and emerging clinical practices aimed at tailoring treatments based on a tumor's molecular alterations with the hope of improving patient response and survival.
- Subjects :
- Pulmonary and Respiratory Medicine
Oncology
Cancer Research
medicine.medical_specialty
Lung Neoplasms
Microarray
Colorectal cancer
Disease
Adenocarcinoma
Methylation
Genome
03 medical and health sciences
0302 clinical medicine
Prostate
Squamous cell carcinoma
Carcinoma, Non-Small-Cell Lung
Internal medicine
medicine
Sequencing
Humans
Molecular Targeted Therapy
Lung cancer
030304 developmental biology
0303 health sciences
business.industry
CNA
Histological subtypes
medicine.disease
Personalized medicine
3. Good health
medicine.anatomical_structure
Actionable alterations
030220 oncology & carcinogenesis
Carcinoma, Squamous Cell
business
Signal Transduction
Subjects
Details
- ISSN :
- 01695002
- Volume :
- 82
- Database :
- OpenAIRE
- Journal :
- Lung Cancer
- Accession number :
- edsair.doi.dedup.....6c136c773a5c698cb56584036cb9addd