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Paper Origami-Inspired Design and Actuation of DNA Nanomachines with Complex Motions
- Source :
- Small (Weinheim an der Bergstrasse, Germany). 14(47)
- Publication Year :
- 2018
-
Abstract
- Significant progress in DNA nanotechnology has accelerated the development of molecular machines with functions like macroscale machines. However, the mobility of DNA self-assembled nanorobots is still dramatically limited due to challenges with designing and controlling nanoscale systems with many degrees of freedom. Here, an origami-inspired method to design transformable DNA nanomachines is presented. This approach integrates stiff panels formed by bundles of double-stranded DNA connected with foldable creases formed by single-stranded DNA. To demonstrate the method, a DNA version of the paper origami mechanism called a waterbomb base (WBB) consisting of six panels connected by six joints is constructed. This nanoscale WBB can follow four distinct motion paths to transform between five distinct configurations including a flat square, two triangles, a rectangle, and a fully compacted trapezoidal shape. To achieve this, the sequence specificity of DNA base-pairing is leveraged for the selective actuation of joints and the ion-sensitivity of base-stacking interactions is employed for the flattening of joints. In addition, higher-order assembly of DNA WBBs into reconfigurable arrays is achieved. This work establishes a foundation for origami-inspired design for next generation synthetic molecular robots and reconfigurable nanomaterials enabling more complex and controllable motion.
- Subjects :
- 0301 basic medicine
Computer science
Base (geometry)
02 engineering and technology
General Chemistry
DNA
Degrees of freedom (mechanics)
021001 nanoscience & nanotechnology
Topology
Molecular machine
Nanostructures
Biomaterials
03 medical and health sciences
030104 developmental biology
DNA nanotechnology
Robot
Nanotechnology
General Materials Science
Nanorobotics
A-DNA
Rectangle
0210 nano-technology
Biotechnology
Subjects
Details
- ISSN :
- 16136829
- Volume :
- 14
- Issue :
- 47
- Database :
- OpenAIRE
- Journal :
- Small (Weinheim an der Bergstrasse, Germany)
- Accession number :
- edsair.doi.dedup.....6c09a99b7cf68416b8ed57a230a4cd1a