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Neutrophil volume distribution width as a new marker in detecting inflammatory bowel disease activation
- Source :
- International journal of laboratory hematology. 39(1)
- Publication Year :
- 2016
-
Abstract
- SummaryIntroduction We sought to investigate the value of neutrophil volume distribution width in detecting inflammatory bowel disease activation. Methods Patients with infection and accompanying inflammatory disease were excluded. All the patients were diagnosed and classified according to Porto criteria and Paris classification, respectively. Physician global assessment, pediatric Crohn's disease and pediatric ulcerative colitis activity indexes and fecal calprotectin were used to define disease activation. Results A total of 34 pediatric patients with Inflammatory bowel diseases (IBD) and 29 controls were enrolled in the study. Neutrophil volume distribution width (NVDW) was significantly higher in patients with IBD compared to healthy controls (P < 0.001). An increased NVDW level was observed in IBD patients in activation (22.42 ± 2.13) compared to those in remission (19.22 ± 1.63) (P < 0.001). There was no statistically significant difference between IBD patients in remission and healthy controls. The best cutoff of NVDW for prediction of disease activation in Crohn's disease and ulcerative colitis in this series was 20.39 with a sensitivity of 90.9% and a specificity of 75% (AUC: 0.852 CI: 0.698–1.000 P < 0.001) and 19.74 with a sensitivity of 92.9% and a specificity of 90.9% (AUC: 0.961, CI: 0.889–1.000, P < 0.001), respectively. Conclusions As a quantitative, objective, and sensitive parameter, we believe that the NVDW has a potential to be an additional test detecting disease activation in IBD.
- Subjects :
- 0301 basic medicine
Adult
Male
medicine.medical_specialty
Adolescent
Neutrophils
Clinical Biochemistry
Disease
Gastroenterology
Inflammatory bowel disease
03 medical and health sciences
0302 clinical medicine
Crohn Disease
Internal medicine
Medicine
Humans
In patient
Child
Volume of distribution
Crohn's disease
business.industry
Biochemistry (medical)
Significant difference
Infant
Hematology
General Medicine
medicine.disease
Ulcerative colitis
digestive system diseases
030104 developmental biology
Child, Preschool
Immunology
030211 gastroenterology & hepatology
Female
Calprotectin
business
Biomarkers
Subjects
Details
- ISSN :
- 1751553X
- Volume :
- 39
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- International journal of laboratory hematology
- Accession number :
- edsair.doi.dedup.....6c047a95457786b7b4a6a158e9bde237