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Replicative cis-advantage of Polyomavirus regulatory region mutants in different murine cell lines
- Publication Year :
- 1987
- Publisher :
- American Society for Microbiology / DC:1752 N Street Northwest:Washington, DC 20036:(202)737-3600, EMAIL: jadelman@asmusa.org, INTERNET: http://www.asmusa.org/asm.htm, Fax: (202)942-9342, 1987.
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Abstract
- To determine the relative growth advantages of polyomavirus regulatory region mutants selected from Friend leukemic and neuroblastoma cells persistently infected with polyomavirus A2 wild type, different murine cell lines, some of which are capable of further differentiation in vitro, were used as hosts in mixed infection and transfection. The tests allowed the determination, through the measurement of cis-advantage in replication, of the most effective polyomavirus regulatory region constitutions for a given cell line and, in some cases, for specific stages of cell differentiation. Furthermore, different domains of the viral regulatory region were shown to have different effects--positive, neutral, or negative--depending on the host analyzed.
- Subjects :
- DNA Replication
Genes, Viral
Cellular differentiation
viruses
Immunology
Biology
medicine.disease_cause
Transfection
Virus Replication
Microbiology
Cell Line
Mice
Virology
Genes, Regulator
medicine
Animals
Tissue Distribution
Mutation
Wild type
DNA replication
Cell Differentiation
Molecular biology
Enhancer Elements, Genetic
Viral replication
Cell culture
Insect Science
DNA, Viral
Polyomavirus
Oncovirus
Research Article
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....6bff50febdb14c621494d01c1a4ce3fc