The nonfunctional allele TCRBV6S1B is strongly associated with Helicobacter pylori infection

To determine genetic susceptibility factors forHelicobacter pyloriinfection, polymorphic T-cell receptor gene elements were investigated in 203H. pylori-infected individuals and 180 uninfected individuals (controls).H. pyloriinfection is highly associated with individuals homozygous for the nonfunctional TCRBV6S1B element (odds ratio = 5.9; χ2= 13;P= 0.00032;Pvalue corrected for multiple comparisons [Bonferroni correction] = 0.00063).