Back to Search
Start Over
Routine Hemostasis and Hemogram Parameters: Valuable Assessments for Coagulation Disorder and Chemotherapy in Cancer Patients
- Source :
- Chinese Medical Journal, Vol 129, Iss 15, Pp 1772-1777 (2016), Chinese Medical Journal
- Publication Year :
- 2016
- Publisher :
- Wolters Kluwer, 2016.
-
Abstract
- Background: The clotting system abnormalities are the common complication in cancer patients. The aim of this retrospective study was to evaluate the coagulation state, clinical features, and treatment in cancer patients by routine tests. Methods: A total of 2328 patients with different types of cancer were classified as the positive group (n = 1419, including 53 patients with thrombosis) and the negative group (n = 909) based on D-dimer (DD) value. Of the 2328 cases, 354 were admitted for chemotherapy. Hemostasis test and complete blood count (CBC) were performed during treatment or following-up. Results: This study showed that the hypercoagulable state was affected not only by clinical staging (P < 0.0001) but also by metastasis site (P < 0.0001 for bone vs. lung). Compared to negative DD group, the higher fibrinogen level, the extended activated partial thromboplastin time, and prothrombin time interacted markedly with disease clinical stage (P < 0.05) in the positive group. Between positive DD groups with and without thrombus, the significantly statistic difference in white blood cell (WBC) and DD (P < 0.05) rather than in red blood cell (RBC) and platelet count was observed. However, the higher DD level was not correlated with WBC, RBC, and platelet count in the positive DD group. Furthermore, the hypercoagulable plasma profile in cancer patients was moderated 2–3 weeks after chemotherapy (P < 0.05 for first six cycles). Conclusions: The routine hemostatic parameters and CBC are valuable to assessment for thrombosis and chemotherapy even for disease prognosis.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
medicine.medical_treatment
lcsh:Medicine
030204 cardiovascular system & hematology
Young Adult
03 medical and health sciences
0302 clinical medicine
Neoplasms
Internal medicine
Chemotherapy
Humans
Medicine
Coagulation Disorder
Cancer
Aged
Retrospective Studies
Aged, 80 and over
Hemostasis
medicine.diagnostic_test
business.industry
Thrombosis
lcsh:R
Complete blood count
Retrospective cohort study
General Medicine
Blood Coagulation Disorders
Middle Aged
medicine.disease
Surgery
030220 oncology & carcinogenesis
Original Article
Female
business
Complication
Subjects
Details
- Language :
- English
- ISSN :
- 03666999
- Volume :
- 129
- Issue :
- 15
- Database :
- OpenAIRE
- Journal :
- Chinese Medical Journal
- Accession number :
- edsair.doi.dedup.....6bd8d350ca9d6029f733853ec0dddaa7