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Effectiveness of Image-Guided Radiotherapy for Locally Advanced Rectal Cancer
- Source :
- Vrije Universiteit Brussel
- Publication Year :
- 2010
- Publisher :
- Springer Science and Business Media LLC, 2010.
-
Abstract
- BACKGROUND: Image-guided radiotherapy (IGRT) combines precise target visualization with optimal delivery of radiation dose to spare normal tissue from radiation and may potentially reduce side-effects and long-term treatment complications. We have assessed the effectiveness of IGRT for locally advanced rectal cancer. METHODS: A retrospective review of 22 patients with locally advanced rectal cancer who underwent preoperative chemoradiation was conducted. RESULTS: Nineteen patients (median age, 69 years) underwent surgical resection after chemoradiation. All 19 patients achieved complete resection with negative margins. Seven patients (32%) had no residual tumor in the surgical specimen. One patient had grade 4 gastrointestinal toxicity and hematological toxicity probably related to inadvertent overdosing of capecitabine. The median survival for the whole group-patients who had pCR and those who did not have pCR-was 14, 17, and 15 months, respectively. CONCLUSIONS: Image-guided radiotherapy provided effective treatment for locally advanced rectal cancer with minimal toxicity and should be investigated in future prospective trials.
- Subjects :
- Diagnostic Imaging
Male
Colorectal cancer
medicine.medical_treatment
Locally advanced
Normal tissue
Antineoplastic Agents
Image guided radiotherapy
Treatment complications
Surgical oncology
medicine
Humans
rectal cancer
Aged
Neoplasm Staging
Retrospective Studies
Image-guided radiation therapy
Aged, 80 and over
Rectal Neoplasms
business.industry
Radiotherapy Planning, Computer-Assisted
Radiotherapy Dosage
Middle Aged
medicine.disease
Combined Modality Therapy
Neoadjuvant Therapy
Survival Rate
Radiation therapy
Treatment Outcome
Oncology
Lymphatic Metastasis
Female
Radiotherapy, Adjuvant
Surgery
Nuclear medicine
business
RADIOTHERAPY
Follow-Up Studies
Subjects
Details
- ISSN :
- 15344681 and 10689265
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Annals of Surgical Oncology
- Accession number :
- edsair.doi.dedup.....6bba7cd6890f5beca0f9b4119ebefd88